Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34259 | 0.98 | GAA (0.48) | GAAMAPT | |
| Ammonia Solution, Strong SCHEMBL4151802 | 0.95 | GAA (0.46) | GAAMAPT | |
| SCHEMBL8654087 | 0.95 | GAA (0.46) | GAAMAPT | |
| SCHEMBL29181632 | 0.95 | GAA (0.46) | GAAMAPT | |
| Hydrochloric Acid SCHEMBL160640 | 0.95 | GAA (0.46) | GAAMAPT | |
| Water SCHEMBL4672877 | 0.95 | GAA (0.46) | GAAMAPT | |
| SCHEMBL1787947 | 0.95 | GAA (0.46) | GAAMAPT | |
| Water SCHEMBL16465946 | 0.95 | GAA (0.46) | GAAMAPT | |
| Iodide SCHEMBL12466756 | 0.95 | GAA (0.46) | GAAMAPT | |
| SCHEMBL8654084 | 0.95 | GAA (0.46) | GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106164044-B | Process for producing 1-arylimino-2-vinylcyclopropanecarboxylic acid derivative | 株式会社钟化 | 2018-05-04 | — | — | CN | disclosed |
| CN-106164044-A | Process for producing 1-arylimino-2-vinylcyclopropanecarboxylic acid derivative | 株式会社钟化 | 2016-11-23 | — | — | CN | disclosed |
| US-20150133537-A1 | 3 - (1' - ADAMANTYL) - 1 - AMINOMETHYL - 3, 4 - DIHYDRO - 5, 6 - DIHYDROXY - 1H - 2 - BENZOPYRAN FOR USE IN THE TREATMENT OF A DISEASE ASSOCIATED WITH BETA-AMYLOID INDUCED TOXICITY | THE UNIVERSITY OF MANCHESTER (GB) | 2015-05-14 | — | — | US | disclosed |
| CN-1859949-A | New derivative of 4A,5,9,10,11,12-tetrahydro-6H-benzofuro[3A, 3, 2-EF] [2] benzazepinium bromide, method of preparation thereof and use in the production of medicaments | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2006-11-08 | — | — | CN | disclosed |
| CN-1859949-A | New derivative of 4A,5,9,10,11,12-tetrahydro-6H-benzofuro[3A, 3, 2-EF] [2] benzazepinium bromide, method of preparation thereof and use in the production of medicaments | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2006-11-08 | — | — | CN | disclosed |
| EP-0127423-B1 | 1-(4'-BRANCHED ALKYLSULFONYLPHENYL)-6-CHLORO-7,8-DIHYDROXY-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES | SMITHKLINE BECKMAN CORPORATION (US) | 1988-02-03 | — | — | EP | disclosed |
| EP-0072029-B1 | TRIAZOLOBENZAZEPINES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1986-10-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133537-A1 | 3 - (1' - ADAMANTYL) - 1 - AMINOMETHYL - 3, 4 - DIHYDRO - 5, 6 - DIHYDROXY - 1H - 2 - BENZOPYRAN FOR USE IN THE TREATMENT OF A DISEASE ASSOCIATED WITH BETA-AMYLOID INDUCED TOXICITY | APP, PSEN1, BACE1 | GAA 269/4885MAPT 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.