Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | F2 | P00734 | 3/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9811381 | 0.89 | KMT2A (0.46) | MEN1KMT2ATDP1L3MBTL1VCAM1 | |
| SCHEMBL10651980 | 0.85 | KMT2A (0.47) | MEN1KMT2AF2PRSS1PRSS2 | |
| SCHEMBL10738160 | 0.81 | MEN1 (0.42) | MEN1KMT2AF2PRSS1PRSS2 | |
| Oxalic Acid SCHEMBL10738176 | 0.79 | MEN1 (0.44) | MEN1KMT2AF2PRSS1PRSS2 | |
| SCHEMBL31651001 | 0.77 | KMT2A (0.58) | MEN1KMT2AF2PRSS1PRSS2 | |
| SCHEMBL31651003 | 0.77 | KMT2A (0.58) | MEN1KMT2AF2PRSS1PRSS2 | |
| SCHEMBL10650939 | 0.75 | KMT2A (0.51) | MEN1KMT2ATDP1L3MBTL1VCAM1 | |
| SCHEMBL10650928 | 0.75 | KMT2A (0.51) | MEN1KMT2ATDP1L3MBTL1VCAM1 | |
| SCHEMBL10566821 | 0.74 | KMT2A (0.45) | MEN1KMT2AF2PRSS1PRSS2 | |
| Hydrochloric Acid SCHEMBL10652496 | 0.74 | VCAM1 (0.42) | MEN1KMT2AF2PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0197386-B1 | 2-(SUBSTITUTED SULFAMYL) DERIVATIVES OF 6-NITROBENZOIC ACID, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1988-11-02 | — | — | EP | disclosed |
| US-4647588-A | 2-(substituted sulfamyl)-6-nitrobenzoic acid amides and pharmaceutical compositions | MERCK & CO., INC. (US) | 1987-03-03 | — | — | US | disclosed |
| EP-0197386-A1 | 2-(Substituted sulfamyl) derivatives of 6-nitrobenzoic acid, process for their preparation and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-10-15 | — | — | EP | disclosed |