Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2733855 | 0.87 | HDAC1 (0.68) | HDAC1HDAC2 | |
| SCHEMBL3565545 | 0.87 | HDAC1 (0.66) | HDAC1HDAC2HDAC3 | |
| SCHEMBL3568796 | 0.85 | HDAC1 (0.71) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL1064455 | 0.81 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC7HDAC8 | |
| SCHEMBL1080617 | 0.81 | HDAC1 (0.71) | HDAC1HDAC2 | |
| SCHEMBL3560308 | 0.81 | HDAC1 (0.55) | HDAC1 | |
| SCHEMBL1081112 | 0.81 | TUBB4A (0.53) | HDAC1 | |
| SCHEMBL6288990 | 0.78 | HDAC1 (0.51) | HDAC1HDAC2HDAC3HDAC7HDAC8 | |
| SCHEMBL3576523 | 0.77 | HDAC1 (0.58) | HDAC1HDAC2HDAC3HDAC7HDAC8 | |
| SCHEMBL3571974 | 0.77 | HDAC1 (0.62) | HDAC1HDAC2HDAC3HDAC7HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |
| WO-2003024448-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2003-03-27 | — | — | WO | disclosed |