Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 10/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9041820 | 0.84 | ALDH1A1 (0.63) | TYMSMAPK1ALDH1A1HPGDTSHR | |
| SCHEMBL15600432 | 0.82 | MAPK1 (0.61) | TYMSMAPK1ALDH1A1HPGDTSHR | |
| SCHEMBL15893312 | 0.76 | ALDH1A1 (0.49) | TYMSMAPK1ALDH1A1HPGDTSHR | |
| SCHEMBL16883560 | 0.76 | ALDH1A1 (0.49) | MAPK1ALDH1A1HPGDTSHRCASP1 | |
| SCHEMBL15600543 | 0.76 | ALDH1A1 (0.49) | MAPK1ALDH1A1HPGDTSHRCASP1 | |
| SCHEMBL20151723 | 0.75 | ALDH1A1 (0.61) | TYMSMAPK1ALDH1A1HPGDTSHR | |
| SCHEMBL15600575 | 0.74 | MAPK1 (0.47) | MAPK1ALDH1A1HPGDTSHRCASP1 | |
| SCHEMBL580216 | 0.74 | CES1 (0.65) | TYMSMAPK1ALDH1A1HPGDTSHR | |
| SCHEMBL15856976 | 0.73 | ALDH1A1 (0.46) | MAPK1ALDH1A1HPGDTSHRCASP1 | |
| SCHEMBL15600574 | 0.73 | ALDH1A1 (0.46) | MAPK1ALDH1A1HPGDTSHRCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108403689-A | The purposes and the application in terms of oncotherapy that radix aristolochiae heterophyllae phenanthrene lactone B lowers FoxM1 genes | 李世龙 | 2018-08-17 | — | — | CN | claimed |
| CN-108403689-A | The purposes and the application in terms of oncotherapy that radix aristolochiae heterophyllae phenanthrene lactone B lowers FoxM1 genes | 李世龙 | 2018-08-17 | — | — | CN | disclosed |
| CN-108403689-A | The purposes and the application in terms of oncotherapy that radix aristolochiae heterophyllae phenanthrene lactone B lowers FoxM1 genes | 李世龙 | 2018-08-17 | — | — | CN | disclosed |
| CN-108403689-A | The purposes and the application in terms of oncotherapy that radix aristolochiae heterophyllae phenanthrene lactone B lowers FoxM1 genes | 李世龙 | 2018-08-17 | — | — | CN | disclosed |
| EP-0090516-B1 | SUBSTITUTED HEXAHYDROPYRROLO(1,2-A)-QUINOLINE, HEXAHYDRO-1H-PYRIDO(1,2-A)-QUINOLINE, HEXAHYDROBENZO(3)INDENE AND OCTAHYDROPHENANTHRENE CNS AGENTS | PFIZER INC. (US) | 1988-07-06 | — | — | EP | disclosed |