Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NMT2 | O60551 | 2/20 | 0.39 |
| ▸ | NMT1 | P30419 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10652338 | 0.82 | MAPT (0.41) | TP53ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10653721 | 0.82 | MEN1 (0.43) | ALDH1A1MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL10654855 | 0.81 | KDM4E (0.50) | TP53ALDH1A1SMN1; SMN2HTTNPSR1 | |
| SCHEMBL10032038 | 0.81 | TP53 (0.51) | TP53ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10652816 | 0.81 | MGAM (0.40) | ALDH1A1MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL10652200 | 0.79 | TACR1 (0.41) | TACR1 | |
| SCHEMBL11707476 | 0.79 | TP53 (0.48) | TP53ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11329170 | 0.77 | TP53 (0.47) | TP53ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11066821 | 0.75 | MEN1 (0.51) | TP53ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10656595 | 0.75 | CHKA (0.42) | ALDH1A1MEN1KMT2ASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0168309-B1 | ISOXAZOLOQUINOLINONE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1988-03-09 | — | — | EP | disclosed |
| US-4588731-A | Derivatives of isoxazolo[4,5-c]quinoline(2H)-3-one and method of preparation and use as anxiolytic agents | ROUSSEL UCLAF (FR) | 1986-05-13 | — | — | US | disclosed |
| EP-0168309-A1 | Isoxazoloquinolinone derivatives, process and intermediates for their preparation, use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1986-01-15 | — | — | EP | disclosed |