Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11707476 | 0.91 | TP53 (0.48) | TP53ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11061534 | 0.88 | TP53 (0.43) | TP53ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11329170 | 0.87 | TP53 (0.47) | TP53ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11066821 | 0.85 | MEN1 (0.51) | TP53ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL440698 | 0.84 | TP53 (0.50) | TP53ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11072096 | 0.83 | NMT1 (0.47) | TP53ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10655729 | 0.81 | TP53 (0.48) | TP53ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL30819200 | 0.80 | ALDH1A1 (0.49) | TP53ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12786944 | 0.80 | ALDH1A1 (0.49) | TP53ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28054743 | 0.78 | HTT (0.51) | ALDH1A1MEN1KMT2ASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142682-A1 | ANTIVIRULENCE COMPOUNDS INHIBITING BACTERIAL MONO-ADP-RIBOSYLTRANSFERASE TOXINS | UNIVERSITY OF GUELPH (CA) | 2012-06-07 | — | — | US | disclosed |
| US-4588731-A | Derivatives of isoxazolo[4,5-c]quinoline(2H)-3-one and method of preparation and use as anxiolytic agents | ROUSSEL UCLAF (FR) | 1986-05-13 | — | — | US | disclosed |
| EP-0067772-B1 | N-DIHYDROTHIAZOLYL-3-QUINOLEINE CARBOXYAMIDE DERIVATIVES, THEIR SALTS, THEIR PREPARATION AND USE AS PHARMACEUTICAL PREPARATIONS, AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1985-03-13 | — | — | EP | disclosed |
| EP-0067772-A1 | N-dihydrothiazolyl-3-quinoleine carboxyamide derivatives, their salts, their preparation and use as pharmaceutical preparations, and pharmaceutical preparations containing them | ROUSSEL-UCLAF (FR) | 1982-12-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142682-A1 | ANTIVIRULENCE COMPOUNDS INHIBITING BACTERIAL MONO-ADP-RIBOSYLTRANSFERASE TOXINS | TIPARP, CD38, PARP14 | TP53 2170/4885ALDH1A1 4539/4885MEN1 2490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.