Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17250764 | 1.00 | KMT2A (0.44) | KMT2APOLBATMIDO1MAPT | |
| SCHEMBL10665995 | 1.00 | KMT2A (0.44) | KMT2APOLBATMIDO1MAPT | |
| SCHEMBL13066415 | 0.81 | KMT2A (0.41) | KMT2APOLBIDO1MAPTALDH1A1 | |
| SCHEMBL21597554 | 0.81 | KMT2A (0.41) | KMT2APOLBIDO1MAPTALDH1A1 | |
| SCHEMBL21597555 | 0.81 | KMT2A (0.41) | KMT2APOLBIDO1MAPTALDH1A1 | |
| SCHEMBL3174311 | 0.81 | KMT2A (0.41) | KMT2APOLBALDH1A1CYP1A2HTT | |
| SCHEMBL4920373 | 0.81 | KMT2A (0.43) | KMT2APOLBMAPTALDH1A1CYP1A2 | |
| SCHEMBL2087130 | 0.81 | KMT2A (0.43) | KMT2APOLBMAPTALDH1A1CYP1A2 | |
| SCHEMBL12793870 | 0.81 | KMT2A (0.43) | KMT2APOLBMAPTALDH1A1CYP1A2 | |
| SCHEMBL13617146 | 0.79 | MAPT (0.40) | KMT2APOLBIDO1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076924-A1 | Piperazines as P2X7 antagonists | ABBOTT LABORATORIES | 2008-03-27 | — | — | US | disclosed |
| EP-0190037-B1 | PROCESS FOR PREPARING AN AZIRIDINE DERIVATIVE | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-11-30 | — | — | EP | disclosed |
| EP-0150937-B1 | DIHYDROPYRIDAZINONES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-09-14 | — | — | EP | disclosed |
| US-4739077-A | Process for preparing an aziridine derivative | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-04-19 | — | — | US | disclosed |
| EP-0190037-A1 | Process for preparing an aziridine derivative | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-08-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076924-A1 | Piperazines as P2X7 antagonists | P2RX7, P2RX1, P2RX2 | KMT2A 3643/4885POLB 4319/4885ATM 4473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.