SCHEMBL1065609

SCHEMBL1065609

Cc1ccc(NC(=O)CCCCCC(=O)Nc2ccccc2N)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 18/20 1.00
HDAC3 O15379 15/20 1.00
HDAC2 Q92769 13/20 1.00
HDAC10 Q969S8 9/20 1.00
HDAC6 Q9UBN7 9/20 0.79
HDAC4 P56524 8/20 0.79
HDAC8 Q9BY41 8/20 0.79
HDAC11 Q96DB2 7/20 0.79
NCOR2 Q9Y618 7/20 0.79
HDAC7 Q8WUI4 6/20 0.79
HDAC9 Q9UKV0 6/20 0.79
HDAC5 Q9UQL6 6/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30013157 1.00 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC10HDAC6
SCHEMBL3237182 0.89 HDAC1 (0.80) HDAC1HDAC3HDAC2HDAC10HDAC6
SCHEMBL12125319 0.89 HDAC1 (0.83) HDAC1HDAC3HDAC2HDAC10HDAC6
SCHEMBL29921577 0.88 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC10HDAC6
SCHEMBL675185 0.88 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC10HDAC6
SCHEMBL1063954 0.88 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC10HDAC6
SCHEMBL30029834 0.88 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC10HDAC6
SCHEMBL16011053 0.87 HDAC4 (1.00) HDAC1HDAC3HDAC2HDAC10HDAC6
SCHEMBL1902019 0.87 HDAC1 (0.97) HDAC1HDAC3HDAC2HDAC10HDAC6
SCHEMBL8241153 0.87 HDAC3 (1.00) HDAC1HDAC3HDAC2HDAC10HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 154 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260125650-A1 METHODS AND COMPOSITIONS FOR GENERATING HEPATOCYTES TRAILHEAD BIOSYSTEMS INC (US) 2026-05-07 US claimed
EP-4728051-A1 STANDARDISING PLURIPOTENT STEM CELLS United Kingdom Research and Innovation (GB) 2026-04-22 EP claimed
EP-4720316-A2 NON-VIRAL CELL ENGINEERING Arsenal Biosciences, Inc. (US) 2026-04-08 EP claimed
US-20250115871-A1 METHODS TO IMPROVE ENDURING HEMATOPOIETIC STEM CELL TRANSPLANTATION TRAILHEAD BIOSYSTEMS INC. 2025-04-10 US claimed
WO-2024259376-A2 NON-VIRAL CELL ENGINEERING ARSENAL BIOSCIENCES, INC. (US) 2024-12-19 WO claimed
WO-2024256607-A1 STANDARDISING PLURIPOTENT STEM CELLS UNITED KINGDOM RESEARCH AND INNOVATION (GB) 2024-12-19 WO claimed
US-20240398814-A1 KRAS INHIBITOR AND HDAC INHIBITOR COMBINATION FOR THE TREATMENT OF CANCER NORTHWESTERN UNIVERSITY 2024-12-05 US claimed
US-20240374569-A1 HDAC3 INHIBITORS FOR THE TREATMENT OF LANGERHANS CELL HISTIOCYTOSIS AND LANGERHANS CELL SARCOMA HENRY FORD HEALTH SYSTEM 2024-11-14 US claimed
EP-4441205-A1 METHODS AND COMPOSITIONS FOR MAINTAINING AND EXPANDING HEMATOPOIETIC STEM CELLS Trailhead Biosystems Inc. (US) 2024-10-09 EP claimed
CN-118302519-A Methods and compositions for maintaining and expanding hematopoietic stem cells 特雷尔赫德生物系统股份有限公司 2024-07-05 CN claimed
US-20230193205-A1 GENE MODIFIED FIBROBLASTS FOR THERAPEUTIC APPLICATIONS FIGENE, LLC 2023-06-22 US claimed
WO-2023101943-A1 METHODS AND COMPOSITIONS FOR MAINTAINING AND EXPANDING HEMATOPOIETIC STEM CELLS TRAILHEAD BIOSYSTEMS INC. (US) 2023-06-08 WO claimed
WO-2023049798-A1 HDAC3 INHIBITORS FOR THE TREATMENT OF LANGERHANS CELL HISTIOCYTOSIS AND LANGERHANS CELL SARCOMA HENRY FORD HEALTH SYSTEM (US) 2023-03-30 WO claimed
WO-2010028193-A1 COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS REPLIGEN CORPORATION (US) 2010-03-11 WO claimed
US-20260125650-A1 METHODS AND COMPOSITIONS FOR GENERATING HEPATOCYTES TRAILHEAD BIOSYSTEMS INC (US) 2026-05-07 US disclosed
EP-4728051-A1 STANDARDISING PLURIPOTENT STEM CELLS United Kingdom Research and Innovation (GB) 2026-04-22 EP disclosed
EP-4719447-A2 METHOD TO GENERATE INDUCED RETINAL PROGENITOR CELLS AND TREATMENT USING SUCH CELLS Academia Sinica (TW) 2026-04-08 EP disclosed
US-20070219244-A1 Histone deacetylase inhibitors as therapeutics for neurological diseases THE SCRIPPS RESEARCH INSTITUTE (US) 2007-09-20 US disclosed
WO-2007058927-A1 HISTONE DEACETYLASE INHIBITORS AS THERAPEUTICS FOR NEUROLOGICAL DISEASES THE SCRIPPS RESEARCH INSTITUTE (US) 2007-05-24 WO disclosed
WO-2007058927-A1 HISTONE DEACETYLASE INHIBITORS AS THERAPEUTICS FOR NEUROLOGICAL DISEASES THE SCRIPPS RESEARCH INSTITUTE (US) 2007-05-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240398814-A1 KRAS INHIBITOR AND HDAC INHIBITOR COMBINATION FOR THE TREATMENT OF CANCER KRAS, HRAS, HDAC1 HDAC1 3/4885HDAC3 9/4885HDAC2 13/4885
US-20070219244-A1 Histone deacetylase inhibitors as therapeutics for neurological diseases HDAC5, HDAC1, HDAC6 HDAC1 2/4885HDAC3 9/4885HDAC2 4/4885
US-20260125650-A1 METHODS AND COMPOSITIONS FOR GENERATING HEPATOCYTES WNT3A, GSK3B, GSK3A HDAC1 71/4885HDAC3 97/4885HDAC2 432/4885
US-20240374569-A1 HDAC3 INHIBITORS FOR THE TREATMENT OF LANGERHANS CELL HISTIOCYTOSIS AND LANGERHANS CELL SARCOMA HDAC3, HDAC1, HDAC2 HDAC1 2/4885HDAC3 1/4885HDAC2 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.