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Sugi Predict / Targets / WNT3A

WNT3A

Protein Wnt-3a · P56704 · WNT3A on Sugi Atlas →

60,275 patent compounds predicted against WNT3A, 30,823 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL247827 SCHEMBL247827 0.69 19/20
SCHEMBL246113 SCHEMBL246113 0.57 18/20
SCHEMBL245851 SCHEMBL245851 0.56 18/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL249352) 0.51 18/20
SCHEMBL248216 SCHEMBL248216 0.69 16/20
SCHEMBL249342 SCHEMBL249342 0.66 16/20
SCHEMBL249965 SCHEMBL249965 0.54 14/20
SCHEMBL246101 SCHEMBL246101 0.65 13/20
Fumaric Acid Fumaric Acid (SCHEMBL248599) 0.59 13/20
Fumaric Acid Fumaric Acid (SCHEMBL248600) 0.59 13/20
SCHEMBL252827 SCHEMBL252827 0.50 13/20
SCHEMBL247792 SCHEMBL247792 0.66 12/20
SCHEMBL70304 SCHEMBL70304 0.61 12/20
SCHEMBL72371 SCHEMBL72371 0.55 12/20
SCHEMBL247828 SCHEMBL247828 0.51 12/20
SCHEMBL247582 SCHEMBL247582 0.50 12/20
SCHEMBL251815 SCHEMBL251815 0.58 11/20
SCHEMBL248465 SCHEMBL248465 0.53 11/20
SCHEMBL249160 SCHEMBL249160 0.53 11/20
SCHEMBL248909 SCHEMBL248909 0.66 10/20

Clinical trials — most relevant to WNT3A by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment PHASE2/PHASE3RECRUITING
Foxy-5 as Neo-Adjuvant Therapy in Subjects With Wnt-5a Low Colon Cancer PHASE2UNKNOWN
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy PHASE2RECRUITING
Mesalazine Effects in Sporadic Colorectal Adenoma Patients PHASE2COMPLETED
Sotrastaurin Acetate in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, Prolymphocytic Leukemia, or Richter's Transformation PHASE2WITHDRAWN
Phase 2 Study Evaluating the Efficacy of the Combination of DKN-01 (DKK1 Inhibitor, Leap Therapeutics) and Pembrolizumab in the Treatment of Advanced or Recurrent Endometrial Cancer PHASE2ACTIVE_NOT_RECRUITING
Comparing of Sesame Oil, Nitroglycerin Ointment, and Aloe Vera Gel PHASE2NOT_YET_RECRUITING
Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetic Profile of XNW7201 in Subjects With Advanced Solid Tumors PHASE1COMPLETED
Safety and Efficacy Study of PRI-724 Plus Gemcitabine in Subjects With Advanced or Metastatic Pancreatic Adenocarcinoma PHASE1COMPLETED
A Phase 1-2 of ST316 With Selected Advanced Unresectable and Metastatic Solid Tumors PHASE1RECRUITING
Tegavivint With Gemcitabine in Patients With Relapsed or Refractory Osteosarcoma PHASE1RECRUITING
Effects of Acute Estrogen Therapy on Bone Formation PHASE1COMPLETED
Phase I Study to Evaluate Safety, Tolerability, Anti-Tumour Activity and PK Profiles of Foxy-5 in Metastatic Breast, Colon or Prostate Cancer PHASE1COMPLETED
A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands PHASE1COMPLETED
Bone Markers and Bone Density Changes in Hyperperparathyroid Dialysis Patients Under Cinacalcet Treatment nanCOMPLETED
Expanded Access Use of DKN-01 for the Treatment of Advanced Solid Tumors nanNO_LONGER_AVAILABLE
Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins nanCOMPLETED
Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion Injury nanUNKNOWN
Osteogenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling nanCOMPLETED
Peripheral Blood Stem Cells Obtained From Normal Volunteers for Studying Retroviral Vector Mediated Gene Transfer Into Primitive Hematopoietic Cells and Vector Mediated Transgene Expression in Mature Hematopoietic Lineages nanCOMPLETED
Klotho _ LRP-6 _ Gastric Adenocarcinoma nanUNKNOWN
Tension-Type Headache Gene Expression and Methylation nanAVAILABLE
The Impact of Mitochondrial Dysfunction on Human Bone Cell Metabolism and Remodelling nanACTIVE_NOT_RECRUITING
Serum Sclerostin Levels, Cardiovascular Parameters and Carpal Tunnel Syndrome in Maintenance Hemodialysis Patients nanUNKNOWN
Cycling Duration and Bone Markers in in Active Young Adults nanWITHDRAWN
Feasibility Trial of Preoperative 5-Day Hypofractionated Radiotherapy for Primary Soft Tissue Sarcoma nanACTIVE_NOT_RECRUITING
Derivation of New Human Embryonic Stem Cell Lines Lines for Clinical Use nanRECRUITING
Eosinophil Induced Remodelling in Asthma nanCOMPLETED
Rheumatoid Arthritis and Osteosarcopenia: Associated Factors nanRECRUITING
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a WNT3A binder may also engage these)

ProteinNameSimilarity
P27467 — 1.000 P27467 →
Q2LMP1 — 0.996 Q2LMP1 →
P31285 — 0.992 P31285 →
WNT3 Proto-oncogene Wnt-3 0.987 landscape →
P17553 — 0.985 P17553 →
P31284 — 0.957 P31284 →
P42642 — 0.935 P42642 →
P28686 — 0.932 P28686 →
Q76LW2 — 0.925 Q76LW2 →
O18739 — 0.922 O18739 →
Q5R9Y1 — 0.922 Q5R9Y1 →
Q9R1V4 — 0.921 Q9R1V4 →
Q96CW9 — 0.921 Q96CW9 →
GLS Glutaminase kidney isoform, mitochondrial 0.921 landscape →
Q9GKY0 — 0.920 Q9GKY0 →
Q6UXG2 — 0.920 Q6UXG2 →
P52848 — 0.920 P52848 →
Q9R1E9 — 0.919 Q9R1E9 →
A2AFS3 — 0.919 A2AFS3 →
P13264 — 0.919 P13264 →
Q62356 — 0.918 Q62356 →
Q12841 — 0.918 Q12841 →
Q3UHN9 — 0.918 Q3UHN9 →
Q58D84 — 0.918 Q58D84 →
Q9P0K9 — 0.918 Q9P0K9 →
Q02353 — 0.917 Q02353 →
D3Z7P3 — 0.917 D3Z7P3 →
Q01098 — 0.917 Q01098 →
GRIN2C Glutamate receptor ionotropic, NMDA 2C 0.916 landscape →
G3MWR8 — 0.916 G3MWR8 →