Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NAT1 | P18440 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10743231 | 1.00 | KDM4E (0.49) | KDM4ECYP1A2CYP2C19TTRALDH1A1 | |
| SCHEMBL2442644 | 0.76 | HPGD (0.50) | KDM4ECYP1A2ALDH1A1KMT2AMEN1 | |
| SCHEMBL13355216 | 0.76 | HPGD (0.50) | KDM4ECYP1A2ALDH1A1KMT2AMEN1 | |
| SCHEMBL2442647 | 0.76 | HPGD (0.50) | KDM4ECYP1A2ALDH1A1KMT2AMEN1 | |
| SCHEMBL7010383 | 0.74 | MAPT (0.52) | KDM4EALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL9794714 | 0.73 | MAPT (0.56) | KDM4EALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL9794716 | 0.73 | MAPT (0.56) | KDM4EALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL9794697 | 0.72 | MAPT (0.57) | KDM4ECYP1A2CYP2C19ALDH1A1KMT2A | |
| SCHEMBL12127310 | 0.72 | KDM4E (0.58) | KDM4ECYP1A2CYP2C19ALDH1A1TSHR | |
| SCHEMBL30395714 | 0.72 | KDM4E (0.58) | KDM4ECYP1A2CYP2C19ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0160256-B1 | CONDENSED FURANONES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | BAYER AG (DE) | 1988-09-28 | — | — | EP | disclosed |
| US-4762853-A | 1-oxo-1,3,4,7-tetrahydrobenzo[C]furans | BAYER AKTIENGESELLSCHAFT (DE) | 1988-08-09 | — | — | US | disclosed |
| US-4668691-A | Circulation-active novel 7-aryl-or pyridyl-1-oxo-1,c,4,7-tetrahydrobenzofurans | BAYER AKTIENGESELLSCHAFT (DE) | 1987-05-26 | — | — | US | disclosed |
| EP-0160256-A2 | Condensed furanones, process for their preparation and their pharmaceutical use | BAYER AG (DE) | 1985-11-06 | — | — | EP | disclosed |