Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 17/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 15/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 10/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10665497 | 0.87 | ADRB3 (0.56) | ADRB3ADRB1ADRB2 | |
| SCHEMBL11041085 | 0.86 | ADRB3 (0.46) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL7153666 | 0.82 | ADRB3 (0.77) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL10508374 | 0.82 | ADRB3 (0.77) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL11172401 | 0.82 | ADRB3 (0.77) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL9006725 | 0.82 | ADRB3 (0.77) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL11174788 | 0.82 | ADRB3 (0.77) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL7153662 | 0.82 | ADRB3 (0.77) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL7148551 | 0.79 | ADRB3 (0.53) | ADRB3ADRB1ADRB2 | |
| SCHEMBL7148552 | 0.79 | ADRB3 (0.53) | ADRB3ADRB1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4753962-A | HYPOGLYCEMIC, ANTIOBESITY AGENT | BEECHAM GROUP P.L.C. (GB) | 1988-06-28 | — | — | US | disclosed |
| US-4654371-A | ANTI-OBESITY, HYPOGLYCEMIA AGENTS | BEECHAM GROUP P.L.C. (GB) | 1987-03-31 | — | — | US | disclosed |
| US-4478849-A | HYPERGLYCEMIC AGENTS | BEECHAM GROUP LIMITED (GB) | 1984-10-23 | — | — | US | disclosed |
| EP-0006735-B1 | SECONDARY AMINES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE | BEECHAM GROUP PLC (GB) | 1983-06-15 | — | — | EP | disclosed |
| EP-0006735-A1 | Secondary amines, their preparation, pharmaceutical compositions containing them and their use | BEECHAM GROUP PLC (GB) | 1980-01-09 | — | — | EP | disclosed |