Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.57 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 8/20 | 0.51 |
| ▸ | CTSK | P43235 | 7/20 | 0.51 |
| ▸ | CTSB | P07858 | 3/20 | 0.49 |
| ▸ | PPARA | Q07869 | 5/20 | 0.49 |
| ▸ | PPARG | P37231 | 4/20 | 0.49 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.48 |
| ▸ | ITGAV | P06756 | 1/20 | 0.48 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.47 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10657027 | 1.00 | ACE (0.57) | ACEITGB3ITGA2BPTPN1CTSS | |
| SCHEMBL23447587 | 0.89 | KLK5 (0.52) | ACECTSSCTSKCTSBCTSL | |
| SCHEMBL4786137 | 0.89 | ACE (0.60) | ACEITGB3ITGA2BPTPN1CTSS | |
| SCHEMBL1172086 | 0.89 | ACE (0.60) | ACEITGB3ITGA2BPTPN1CTSS | |
| SCHEMBL30829409 | 0.89 | ACE (0.60) | ACEITGB3ITGA2BPTPN1CTSS | |
| SCHEMBL31525018 | 0.88 | ACE (0.59) | ACEITGB3ITGA2BPTPN1CTSS | |
| SCHEMBL15565481 | 0.86 | ACE (0.58) | ACEITGB3ITGA2BPTPN1CTSS | |
| SCHEMBL13286814 | 0.86 | ACE (0.58) | ACEITGB3ITGA2BPTPN1CTSS | |
| SCHEMBL24489644 | 0.85 | FOLH1 (0.62) | ACEITGB3ITGA2BPTPN1CTSS | |
| SCHEMBL2631434 | 0.85 | PTPN1 (0.59) | ACEITGB3ITGA2BPTPN1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722922-A | RENIN INHIBITION | G. D. SEARLE & CO. (US) | 1988-02-02 | — | — | US | disclosed |
| US-4603121-A | ANALGESICS | G. D. SEARLE & CO. (US) | 1986-07-29 | — | — | US | disclosed |
| EP-0136720-A2 | Enkephalin analogs | G.D. Searle & Co. (US) | 1985-04-10 | — | — | EP | disclosed |
| US-4495178-A | Enkephalin analogs | G. D. SEARLE & CO. (US) | 1985-01-22 | — | — | US | disclosed |