Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | EEF2K | O00418 | 1/20 | 0.46 |
| ▸ | ADK | P55263 | 3/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | STK4 | Q13043 | 1/20 | 0.39 |
| ▸ | STK3 | Q13188 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7938993 | 0.88 | KDM4E (0.49) | KDM4EGAAADKPIK3CASMN1; SMN2 | |
| SCHEMBL8850966 | 0.85 | ADK (0.43) | KDM4EGAAADKPIK3CASMN1; SMN2 | |
| SCHEMBL10663828 | 0.83 | ADK (0.41) | KDM4EGAAADKPIK3CASMN1; SMN2 | |
| SCHEMBL10660762 | 0.81 | HTT (0.39) | KDM4EGAAEEF2KHTTRPS6KB1 | |
| SCHEMBL10661136 | 0.80 | SMN1; SMN2 (0.50) | KDM4EGAAADKPIK3CASMN1; SMN2 | |
| SCHEMBL10660765 | 0.80 | SMN1; SMN2 (0.41) | KDM4EGAAADKSMN1; SMN2HTT | |
| SCHEMBL7930954 | 0.79 | SMN1; SMN2 (0.49) | KDM4EGAAADKSMN1; SMN2CYP1A2 | |
| SCHEMBL10662972 | 0.79 | ADK (0.41) | KDM4EGAAADKPIK3CASMN1; SMN2 | |
| SCHEMBL10659904 | 0.79 | SMN1; SMN2 (0.43) | KDM4EGAAADKSMN1; SMN2ADORA2A | |
| SCHEMBL10659846 | 0.78 | KDM4E (0.49) | KDM4EGAAEEF2KADKPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4728646-A | ANTITHROMBOTICS | DR. KARL THOMAE GMBH (DE) | 1988-03-01 | — | — | US | disclosed |
| US-4690923-A | ANTITHROMBOTICS | KARL THOMAE GMBH (DE) | 1987-09-01 | — | — | US | disclosed |
| US-4518596-A | Antithrombotic use of 2-(perhydro-1,4-diazino)-pyrimido (5,4,D)-pyrimidines | DR. KARL THOMAE GMBH (DE) | 1985-05-21 | — | — | US | disclosed |
| EP-0023559-B1 | 2-(PERHYDRO-1,4-DIAZINO)-PYRIMIDO(5,4-D)PYRIMIDINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1984-09-19 | — | — | EP | disclosed |
| EP-0023559-A1 | 2-(Perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1981-02-11 | — | — | EP | disclosed |