Sugi Predict

Sugi Predict / Compounds / SCHEMBL10657964

SCHEMBL10657964

SCHEMBL10657964

Cc1sc2c(Cl)nccc2c1C

nearest known ligand 0.34

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ APEX1 P27695 1/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ PMP22 Q01453 1/20 0.34
▸ ROCK1 Q13464 4/20 0.32
▸ DYRK1A Q13627 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27083414 0.85 LMNA (0.34) LMNACYP3A4MAPTAPEX1MAPK1
SCHEMBL29210403 0.81 LMNA (0.33) LMNACYP3A4MAPTAPEX1MAPK1
SCHEMBL2261606 0.81 LMNA (0.33) LMNACYP3A4MAPTAPEX1MAPK1
SCHEMBL25171507 0.77 MAPT (0.35) LMNACYP3A4MAPTAPEX1MAPK1
SCHEMBL30366781 0.74 CHRM4 (0.35) LMNACYP3A4MAPTAPEX1MAPK1
SCHEMBL25464252 0.74 LMNA (0.33) LMNACYP3A4MAPTAPEX1MAPK1
SCHEMBL23775116 0.74 CHRM4 (0.35) LMNACYP3A4MAPTAPEX1MAPK1
SCHEMBL1811979 0.73 HPGD (0.44) LMNAMAPTMAPK1
SCHEMBL25464236 0.73 LMNA (0.39) LMNACYP3A4MAPTAPEX1MAPK1
SCHEMBL21402329 0.73 CHRM4 (0.37) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0292051-A2 Thienopyridine derivatives SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) 1988-11-23 — — EP disclosed