Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 12/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.41 |
| ▸ | CASP1 | P29466 | 7/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 7/20 | 0.40 |
| ▸ | CASP7 | P55210 | 6/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | HBB | P68871 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10657751 | 0.84 | CNR1 (0.46) | MAPTTHRBTP53MEN1KMT2A | |
| SCHEMBL10657891 | 0.80 | MAPT (0.47) | MAPTTHRBCYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL10655505 | 0.78 | PLK1 (0.44) | MAPTCYP1A2CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL10656189 | 0.78 | MAPT (0.46) | MAPTTHRBCYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL10654520 | 0.77 | KDM4E (0.38) | MAPTALDH1A1HSD17B10CASP1CASP7 | |
| SCHEMBL9629927 | 0.73 | PDE4A (0.48) | CYP1A2ALDH1A1HSD17B10CYP2C9CYP2C19 | |
| SCHEMBL10377474 | 0.72 | HPGD (0.48) | CYP1A2ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL10427753 | 0.71 | MAPT (0.52) | MAPTTHRBCYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL10378372 | 0.71 | HPGD (0.47) | MAPTTHRBCYP1A2ALDH1A1TP53 | |
| SCHEMBL9629754 | 0.71 | HPGD (0.47) | MAPTCYP1A2ALDH1A1HSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |