Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10656168 | 0.83 | KDR (0.61) | RAB9AMEN1KMT2AMAPTLMNA | |
| SCHEMBL10661685 | 0.82 | KMT2A (0.71) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL30369807 | 0.80 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL4254257 | 0.80 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2681347 | 0.80 | NPC1 (0.80) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL3228267 | 0.79 | CXCR2 (0.68) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL6557523 | 0.79 | NPC1 (0.77) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL8460312 | 0.79 | NPC1 (0.78) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL6078205 | 0.78 | NPC1 (0.75) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL95599 | 0.78 | NPC1 (0.75) | NPC1RAB9AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4728658-A | ANTIULCER | JOHN WYETH & BROTHER LIMITED (GB) | 1988-03-01 | — | — | US | claimed |
| US-4728658-A | ANTIULCER | JOHN WYETH & BROTHER LIMITED (GB) | 1988-03-01 | — | — | US | disclosed |