Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 16/20 | 0.69 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.58 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11142453 | 0.94 | ADRB2 (0.64) | ADRB2ADRB1ADRA1AADRA1DADRA1B | |
| SCHEMBL10662466 | 0.91 | ADRB2 (0.58) | ADRB2ADRB1ADRA1AADRA1DADRA1B | |
| SCHEMBL10658025 | 0.91 | ADRB2 (0.59) | ADRB2ADRB1ADRA1AADRA1DADRA1B | |
| SCHEMBL9664001 | 0.89 | ADRB2 (0.63) | ADRB2ADRB1ADRA1AADRB3SLC6A4 | |
| SCHEMBL10661718 | 0.89 | ADRB2 (0.63) | ADRB2ADRB1ADRA1AADRB3SLC6A4 | |
| SCHEMBL10662533 | 0.89 | ADRB2 (0.63) | ADRB2ADRB1ADRA1AADRB3SLC6A4 | |
| SCHEMBL11139901 | 0.85 | ADRB2 (0.61) | ADRB2ADRB1ADRB3CYP2D6KDM4E | |
| SCHEMBL9811975 | 0.84 | ADRB2 (0.80) | ADRB2ADRB1ADRA1AADRA1DADRB3 | |
| SCHEMBL9811981 | 0.84 | ADRB2 (0.80) | ADRB2ADRB1ADRA1AADRA1DADRB3 | |
| SCHEMBL11480459 | 0.83 | ADRB2 (0.78) | ADRB2ADRB1ADRA1AADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4753962-A | HYPOGLYCEMIC, ANTIOBESITY AGENT | BEECHAM GROUP P.L.C. (GB) | 1988-06-28 | — | — | US | disclosed |
| US-4654371-A | ANTI-OBESITY, HYPOGLYCEMIA AGENTS | BEECHAM GROUP P.L.C. (GB) | 1987-03-31 | — | — | US | disclosed |
| US-4478849-A | HYPERGLYCEMIC AGENTS | BEECHAM GROUP LIMITED (GB) | 1984-10-23 | — | — | US | disclosed |
| EP-0006735-B1 | SECONDARY AMINES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE | BEECHAM GROUP PLC (GB) | 1983-06-15 | — | — | EP | disclosed |
| EP-0006735-A1 | Secondary amines, their preparation, pharmaceutical compositions containing them and their use | BEECHAM GROUP PLC (GB) | 1980-01-09 | — | — | EP | disclosed |