SCHEMBL10658941

SCHEMBL10658941

COc1ccc(C=O)c(O)c1Cl

nearest known ligand 0.58

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 15/20 0.58
TLR2 O60603 1/20 0.58
TLR1 Q15399 1/20 0.58
TLR6 Q9Y2C9 1/20 0.58
ALDH1A1 P00352 2/20 0.46
TRIM24 O15164 1/20 0.44
TYR P14679 1/20 0.44
TRIM33 Q9UPN9 1/20 0.44
AOX1 Q06278 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1299161 0.85 ERN1 (0.58) ERN1TLR2TLR1TLR6ALDH1A1
SCHEMBL4898660 0.82 ALDH1A1 (0.50) ERN1TLR2TLR1TLR6ALDH1A1
SCHEMBL1527154 0.82 ERN1 (0.69) ERN1TLR2TLR1TLR6ALDH1A1
SCHEMBL19025079 0.81 ERN1 (0.51) ERN1TLR2TLR1TLR6ALDH1A1
SCHEMBL3658867 0.79 ERN1 (0.59) ERN1TLR2TLR1TLR6ALDH1A1
SCHEMBL4011543 0.79 ALDH1A1 (0.47) ERN1TLR2TLR1TLR6ALDH1A1
SCHEMBL29683824 0.79 ERN1 (0.59) ERN1TLR2TLR1TLR6ALDH1A1
SCHEMBL29628664 0.79 ALDH1A1 (0.47) ERN1TLR2TLR1TLR6ALDH1A1
SCHEMBL6202266 0.79 ALDH1A1 (0.47) ERN1TLR2TLR1TLR6ALDH1A1
SCHEMBL5645697 0.79 ERN1 (0.59) ERN1TLR2TLR1TLR6ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260092052-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICALS CO (JP) 2026-04-02 US disclosed
US-20240109874-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICALS CO (JP) 2024-04-04 US disclosed
EP-3728267-B1 TRICYCLIC INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF ONTARIO INSTITUTE FOR CANCER RES OICR (CA) 2023-09-13 EP disclosed
EP-3728267-B1 TRICYCLIC INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF ONTARIO INSTITUTE FOR CANCER RES OICR (CA) 2023-09-13 EP disclosed
US-20220411413-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICALS CO (JP) 2022-12-29 US disclosed
US-11242351-B2 Tricyclic inhibitors of the BCL6 BTB domain protein-protein interaction and uses thereof ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) 2022-02-08 US disclosed
US-11242351-B2 Tricyclic inhibitors of the BCL6 BTB domain protein-protein interaction and uses thereof ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) 2022-02-08 US disclosed
US-20210053978-A1 TRICYCLIC INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) 2021-02-25 US disclosed
US-20210053978-A1 TRICYCLIC INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) 2021-02-25 US disclosed
US-20210009572-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICALS CO (JP) 2021-01-14 US disclosed
WO-2015163485-A1 ISOINDOLINE-1-ONE DERIVATIVES AS CHOLINERGIC MUSCARINIC M1 RECEPTOR POSITIVE ALLOESTERIC MODULATOR ACTIVITY FOR THE TREATMENT OF ALZHEIMERS DISEASE TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-10-29 WO disclosed
US-4728662-A DIURETICS, URICOSURICS, HYPOTENSIVES HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1988-03-01 US disclosed
EP-0119294-B1 BENZISOXAZOLE CARBOXYLIC ACIDS ABBOTT LABORATORIES (US) 1987-09-16 EP disclosed
US-4673746-A DIURETICS, HYPOTENSIVES HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1987-06-16 US disclosed
US-4490384-A DIURETICS; HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS ABBOTT LABORATORIES (US) 1984-12-25 US disclosed
EP-0119294-A1 Benzisoxazole carboxylic acids ABBOTT LABORATORIES (US) 1984-09-26 EP disclosed
WO-1984003199-A1 BENZISOXAZOLE CARBOXYLIC ACIDS ABBOTT LAB (US) 1984-08-30 WO disclosed
US-4456612-A DIURETICS ABBOTT LABORATORIES (US) 1984-06-26 US disclosed
EP-0002666-B1 1,2-BENZISOXAZOLYLOXY (OR THIO) ACETIC ACIDS AND RELATED COMPOUNDS, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM HOECHST AKTIENGESELLSCHAFT (DE) 1982-02-17 EP disclosed
EP-0002666-A1 1,2-Benzisoxazolyloxy (or thio) acetic acids and related compounds, process for their preparation and medicines containing them HOECHST AKTIENGESELLSCHAFT (DE) 1979-07-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240109874-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND CHRM1, CHRM5, CHRM2 ERN1 3256/4885TLR2 2150/4885TLR1 795/4885
US-20260092052-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND CHRM1, CHRM2, CHRM4 ERN1 2839/4885TLR2 1565/4885TLR1 674/4885
US-20220411413-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND CHRM1, CHRM5, CHRM2 ERN1 3256/4885TLR2 2150/4885TLR1 795/4885
US-20210009572-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND CHRM1, CHRM5, CHRNA5 ERN1 3869/4885TLR2 1815/4885TLR1 1147/4885
US-20210053978-A1 TRICYCLIC INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF BCL6, BCL6B, BCL3 ERN1 1036/4885TLR2 4336/4885TLR1 3579/4885
US-11242351-B2 Tricyclic inhibitors of the BCL6 BTB domain protein-protein interaction and uses thereof BCL6, BCL6B, BCL3 ERN1 1036/4885TLR2 4336/4885TLR1 3579/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.