Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10662905 | 0.85 | PRKAG1 (0.55) | MAPTAURKAAURKBALDH1A1KDM4E | |
| SCHEMBL9835632 | 0.82 | KMT2A (0.50) | MAPTAURKAAURKBALDH1A1KDM4E | |
| SCHEMBL9834905 | 0.80 | PDE4A (0.47) | MAPTAURKAAURKBALDH1A1KDM4E | |
| SCHEMBL9835346 | 0.80 | PDE3B (0.51) | MAPTAURKAAURKBKDM4EPDE3B | |
| SCHEMBL9835224 | 0.78 | PDE4A (0.46) | MAPTAURKAAURKBKDM4EPDE3B | |
| SCHEMBL9834509 | 0.78 | KMT2A (0.42) | MAPTAURKAAURKBALDH1A1KDM4E | |
| SCHEMBL10668127 | 0.77 | PDE3B (0.48) | MAPTAURKAAURKBALDH1A1PDE3B | |
| SCHEMBL9834481 | 0.76 | PDE3B (0.46) | MAPTAURKAAURKBALDH1A1KDM4E | |
| SCHEMBL14925453 | 0.74 | MAPT (0.72) | MAPTALDH1A1KDM4EPDE3BPDE3A | |
| SCHEMBL10553724 | 0.73 | MAPT (0.57) | MAPTALDH1A1KDM4EPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |
| EP-0214592-A2 | Pyrrolobenzimidazoles, process for their preparation and medicaments containing these products | Roche Diagnostics GmbH (DE) | 1987-03-18 | — | — | EP | disclosed |