Sugi Predict

Sugi Predict / Targets / PRKAG1

PRKAG1

5'-AMP-activated protein kinase subunit gamma-1 · P54619 · PRKAG1 on Sugi Atlas →

67,602 patent compounds predicted against PRKAG1, 41,130 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL176936 SCHEMBL176936 0.55 12/20
SCHEMBL61579 SCHEMBL61579 0.51 12/20
SCHEMBL61866 SCHEMBL61866 0.51 10/20
SCHEMBL68693 SCHEMBL68693 0.47 10/20
SCHEMBL260615 SCHEMBL260615 0.55 9/20
SCHEMBL62208 SCHEMBL62208 0.51 9/20
Trifluoroacetic Acid Trifluoroacetic Acid (SCHEMBL63390) 0.49 9/20
SCHEMBL176882 SCHEMBL176882 0.66 8/20
SCHEMBL91078 SCHEMBL91078 0.59 8/20
SCHEMBL229119 SCHEMBL229119 0.54 8/20
SCHEMBL61772 SCHEMBL61772 0.53 8/20
SCHEMBL261067 SCHEMBL261067 0.45 8/20
SCHEMBL61677 SCHEMBL61677 0.57 7/20
SCHEMBL159594 SCHEMBL159594 0.53 7/20
SCHEMBL228817 SCHEMBL228817 0.52 7/20
SCHEMBL230173 SCHEMBL230173 0.52 7/20
SCHEMBL61254 SCHEMBL61254 0.45 7/20
Dorsomorphin Dorsomorphin (SCHEMBL463155) 1.00 6/20
SCHEMBL157758 SCHEMBL157758 0.58 6/20
SCHEMBL228213 SCHEMBL228213 0.56 6/20

Clinical trials — most relevant to PRKAG1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity PHASE4COMPLETED
Alpha Ketoglutarate Enhances Geroprotection In Surgery (AEGIS) PHASE4RECRUITING
Status of Growth Hormone/ Insulin-like Growth Factor-1 (GH/IGF-1) Axis and Growth Failure in Ataxia Telangiectasia (AT) PHASE4UNKNOWN
Metformin Induces a Dietary Restriction-like State in Human PHASE4UNKNOWN
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
Metformin and Simvastatin Use in Bladder Cancer PHASE2UNKNOWN
Safety and Feasibility of Metformin for Sepsis Induced AKI PHASE2COMPLETED
Efficacy of Amlexanox vs. Placebo in Type 2 Diabetic Patients PHASE2COMPLETED
Metformin as a Novel Therapy for Autosomal Dominant Polycystic Kidney Disease PHASE2COMPLETED
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals PHASE1/PHASE2COMPLETED
Metformin Hydrochloride in Preventing Esophageal Cancer in Patients With Barrett Esophagus PHASE2COMPLETED
PKC412 and 5-Azacytidine PHASE1/PHASE2COMPLETED
Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism. PHASE1COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Sirolimus and Gold Sodium Thiomalate in Treating Patients With Advanced Squamous Non-Small Cell Lung Cancer PHASE1WITHDRAWN
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer EARLY_PHASE1COMPLETED
Effect of Age on Glucose and Lipid Metabolism nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus nanUNKNOWN
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men nanRECRUITING
NASH AMPK Exercise Dosing (AMPED) Trial nanRECRUITING
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
Cardiac and Skeletal Muscle Energy Metabolism in Abnormal Growth Hormone States nanCOMPLETED
Influence of Intermittent Hypoxia on Glycemic Control nanCOMPLETED
The Effect of White Tea Consumption on Obesity nanCOMPLETED
Defective Atypical Protein Kinase C (PKC) Activation in Diabetes and Metabolic Syndrome nanCOMPLETED
Purinergic Signaling and the Postmenopausal Heart nanRECRUITING
Possible Diagnostic Protein Markers in Schistosoma Related Bladder Diseases. nanNOT_YET_RECRUITING
SMYD3-Driven Metabolic Rewiring in Colorectal Liver Metastases nanNOT_YET_RECRUITING
Daily Caloric Restriction and Intermittent Fasting in Overweight and Obese Adults With Autosomal Dominant Polycystic Kidney Disease nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PRKAG1 binder may also engage these)

ProteinNameSimilarity
Q09138 — 1.000 Q09138 →
P80385 — 1.000 P80385 →
P58108 — 1.000 P58108 →
O54950 — 1.000 O54950 →
Q9P869 — 0.986 Q9P869 →
Q10343 — 0.985 Q10343 →
P12904 — 0.985 P12904 →
Q09826 — 0.985 Q09826 →
Q8GXI9 — 0.978 Q8GXI9 →
Q9LF97 — 0.977 Q9LF97 →
Q0WLC7 — 0.977 Q0WLC7 →
Q9SJQ5 — 0.977 Q9SJQ5 →
Q9FMV3 — 0.976 Q9FMV3 →
P78875 — 0.975 P78875 →
P00927 — 0.975 P00927 →
Q5R4S0 — 0.974 Q5R4S0 →
PRKAG2 5'-AMP-activated protein kinase subunit gamma-2 0.974 landscape →
Q91WG5 — 0.974 Q91WG5 →
Q758X6 — 0.973 Q758X6 →
P0DH79 — 0.973 P0DH79 →
A6ZP88 — 0.973 A6ZP88 →
Q6CY37 — 0.973 Q6CY37 →
Q6C3P4 — 0.973 Q6C3P4 →
Q6CVX9 — 0.973 Q6CVX9 →
Q80YE7 — 0.973 Q80YE7 →
Q09509 — 0.972 Q09509 →
Q9GYL2 — 0.972 Q9GYL2 →
O59781 — 0.972 O59781 →
Q08685 — 0.972 Q08685 →
Q9MA88 — 0.972 Q9MA88 →