Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMD1 | P17707 | 2/20 | 0.69 |
| ▸ | DOT1L | Q8TEK3 | 7/20 | 0.68 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.65 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.58 |
| ▸ | DPP4 | P27487 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.57 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.57 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.57 |
| ▸ | GAPDH | P04406 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.57 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.57 |
| ▸ | STAT6 | P42226 | 1/20 | 0.57 |
| ▸ | PI4KA | P42356 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10668844 | 0.91 | AMD1 (0.67) | AMD1DOT1LEZH2PRMT1DPP4 | |
| SCHEMBL15012484 | 0.89 | AMD1 (0.73) | AMD1DOT1LEZH2PRMT1DPP4 | |
| SCHEMBL952218 | 0.89 | AMD1 (0.73) | AMD1DOT1LEZH2PRMT1DPP4 | |
| SCHEMBL952217 | 0.89 | AMD1 (0.73) | AMD1DOT1LEZH2PRMT1DPP4 | |
| SCHEMBL10660872 | 0.88 | DOT1L (0.75) | AMD1DOT1LEZH2PRMT1PRKACA | |
| SCHEMBL995958 | 0.86 | AMD1 (0.77) | AMD1DOT1LEZH2PRMT1DPP4 | |
| SCHEMBL13986400 | 0.86 | AMD1 (0.80) | AMD1DOT1LEZH2DPP4MEN1 | |
| SCHEMBL10665694 | 0.86 | DOT1L (0.68) | AMD1DOT1LEZH2PRMT1PRKACA | |
| SCHEMBL1770046 | 0.85 | AMD1 (0.76) | AMD1DOT1LEZH2DPP4MEN1 | |
| SCHEMBL1770049 | 0.85 | AMD1 (0.76) | AMD1DOT1LEZH2DPP4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4794174-A | ENZYME INHIBITORS | SOUTHERN RESEARCH INSTITUTE (US) | 1988-12-27 | — | — | US | disclosed |