Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 18/20 | 0.73 |
| ▸ | ACE2 | Q9BYF1 | 10/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10664899 | 0.91 | ACE (0.72) | ACEACE2 | |
| SCHEMBL10847107 | 0.91 | ACE (0.72) | ACEACE2 | |
| SCHEMBL10848104 | 0.88 | ACE (0.58) | ACEACE2 | |
| SCHEMBL10669883 | 0.85 | ACE (0.71) | ACEACE2 | |
| SCHEMBL1792093 | 0.84 | ACE (1.00) | ACEACE2 | |
| SCHEMBL11123161 | 0.84 | ACE (1.00) | ACEACE2 | |
| SCHEMBL1792089 | 0.84 | ACE (1.00) | ACEACE2 | |
| SCHEMBL7360582 | 0.84 | ACE (0.74) | ACEACE2 | |
| SCHEMBL7360576 | 0.84 | ACE (0.74) | ACEACE2 | |
| Hydrochloric Acid SCHEMBL9536922 | 0.83 | ACE (0.73) | ACEACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4742067-A | Acylalkylaminocarbonyl substituted amino and imino acid compounds | E. R. SQUIBB & SONS, INC. (US) | 1988-05-03 | — | — | US | disclosed |
| US-4623729-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1986-11-18 | — | — | US | disclosed |
| US-4621092-A | HYPOTENSIVE, ANALGESIC | E. R. SQUIBB & SONS, INC. (US) | 1986-11-04 | — | — | US | disclosed |
| US-4604402-A | HYPOTENSIVE AGNETS | E. R. SQUIBB & SONS, INC. (US) | 1986-08-05 | — | — | US | disclosed |
| EP-0159156-A1 | Hydroxy substituted ureido amino and imino acids | E.R. Squibb & Sons, Inc. (US) | 1985-10-23 | — | — | EP | disclosed |
| EP-0103496-A1 | Acylalkylaminocarbonyl substituted amino and imino acid compounds | E.R. Squibb & Sons, Inc. (US) | 1984-03-21 | — | — | EP | disclosed |