Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | AR | P10275 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411297 | 1.00 | BACE1 (0.65) | BACE1ALDH1A1MAPTARMEN1 | |
| SCHEMBL10670403 | 0.88 | BACE1 (0.64) | BACE1ALDH1A1MAPTARMEN1 | |
| SCHEMBL10348541 | 0.88 | BACE1 (0.64) | BACE1ALDH1A1MAPTARMEN1 | |
| SCHEMBL10349049 | 0.88 | BACE1 (0.64) | BACE1ALDH1A1MAPTARMEN1 | |
| SCHEMBL10377588 | 0.87 | BACE1 (0.57) | BACE1ALDH1A1MAPTARMEN1 | |
| SCHEMBL10661946 | 0.87 | BACE1 (0.60) | BACE1ALDH1A1MAPTARMEN1 | |
| SCHEMBL11548849 | 0.85 | BACE1 (0.68) | BACE1ALDH1A1MAPTARMEN1 | |
| SCHEMBL11548851 | 0.85 | BACE1 (0.68) | BACE1ALDH1A1MAPTARMEN1 | |
| SCHEMBL7410951 | 0.84 | GAA (0.59) | BACE1ALDH1A1MAPTARMEN1 | |
| SCHEMBL7412208 | 0.84 | MAPT (0.71) | BACE1ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4727066-A | CARDIOVASCULAR DISORDERS | CERMOL S.A. (CH) | 1988-02-23 | — | — | US | disclosed |
| US-4656181-A | CARDIOTONIC AGENTS | CERMOL S.A. (CH) | 1987-04-07 | — | — | US | disclosed |