Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | BACE1 | P56817 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10349049 | 0.86 | BACE1 (0.64) | GAAHPGDBACE1ALDH1A1KMT2A | |
| SCHEMBL10670403 | 0.86 | BACE1 (0.64) | GAAHPGDBACE1ALDH1A1KMT2A | |
| SCHEMBL10348541 | 0.86 | BACE1 (0.64) | GAAHPGDBACE1ALDH1A1KMT2A | |
| SCHEMBL10661946 | 0.85 | BACE1 (0.60) | GAAHPGDBACE1ALDH1A1KMT2A | |
| SCHEMBL10666396 | 0.84 | BACE1 (0.65) | BACE1ALDH1A1KMT2AMAPTLMNA | |
| SCHEMBL7411297 | 0.84 | BACE1 (0.65) | BACE1ALDH1A1KMT2AMAPTLMNA | |
| SCHEMBL10377588 | 0.83 | BACE1 (0.57) | GAAHPGDBACE1ALDH1A1KMT2A | |
| SCHEMBL10992522 | 0.83 | BACE1 (0.52) | GAAHPGDBACE1ALDH1A1KMT2A | |
| SCHEMBL11518008 | 0.81 | BACE1 (0.58) | GAAHPGDBACE1ALDH1A1KMT2A | |
| SCHEMBL11741315 | 0.81 | BACE1 (0.62) | BACE1ALDH1A1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4622332-A | Asymmetric diesters of Hantzsch dihydropyridines with hypotensive activity | BAYER AKTIENGESELLSCHAFT (DE) | 1986-11-11 | — | — | US | disclosed |
| US-4551467-A | Vasodilating cyanoalkyl esters of 1,4-dihydropyridines | BAYER AKTIENGESELLSCHAFT (DE) | 1985-11-05 | — | — | US | disclosed |
| US-4248873-A | Nitro-substituted 1,4-dihydropyridines, processes for _their production and their medicinal use | BAYER AKTIENGESELLSCHAFT (DE) | 1981-02-03 | — | — | US | disclosed |
| US-4162321-A | Sulphur-containing amino-dihydropyridines, and their use as medicants | BAYER AKTIENGESELLSCHAFT (DE) | 1979-07-24 | — | — | US | disclosed |
| US-4154839-A | INCREASING CORONARY PERFUSION | BAYER AKTIENGESELLSCHAFT (DE) | 1979-05-15 | — | — | US | disclosed |
| US-4044141-A | CORONARY DILATING, SPASMOLYTIC, HYPOTENSIVE AGENTS | BAYER AKTIENGESELLSCHAFT (DT) | 1977-08-23 | — | — | US | disclosed |