Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN4 | Q9Y3Q4 | 6/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10666609 | 0.90 | HCN4 (0.47) | HCN4BRD4SMPD1MAPTCYP3A4 | |
| SCHEMBL10894643 | 0.83 | HCN4 (0.48) | HCN4BRD4SMPD1MAPTCYP3A4 | |
| SCHEMBL10669932 | 0.83 | HCN4 (0.50) | HCN4BRD4SMPD1MAPTCYP3A4 | |
| Hydrochloric Acid SCHEMBL10667216 | 0.82 | HCN4 (0.49) | HCN4BRD4SMPD1MAPTCYP3A4 | |
| SCHEMBL10664298 | 0.82 | HCN4 (0.49) | HCN4BRD4SMPD1MAPTCYP3A4 | |
| SCHEMBL10664291 | 0.82 | HCN4 (0.38) | HCN4SMPD1MAPT | |
| SCHEMBL10670888 | 0.81 | HCN4 (0.51) | HCN4BRD4SMPD1MAPTCYP3A4 | |
| SCHEMBL10663997 | 0.81 | HCN4 (0.64) | HCN4SMPD1MAPTCYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL10671903 | 0.81 | HCN4 (0.51) | HCN4BRD4SMPD1MAPTCYP3A4 | |
| SCHEMBL10663974 | 0.80 | MAPT (0.40) | HCN4SMPD1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4737495-A | ANTIALLERGENS, ANTISCHEMIC, HYPOTENSIVE AGENTS | DR. KARL TOMAE, GMBH (DE) | 1988-04-12 | — | — | US | disclosed |
| EP-0204349-A2 | Heteroaromatic amine derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1986-12-10 | — | — | EP | disclosed |