Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN4 | Q9Y3Q4 | 6/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.42 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10667192 | 0.83 | HCN4 (0.48) | HCN4BRD4SMPD1MAPTCYP3A4 | |
| SCHEMBL10669932 | 0.83 | HCN4 (0.50) | HCN4BRD4SMPD1MAPTCYP3A4 | |
| SCHEMBL10648580 | 0.83 | PDE4D (0.47) | CDK4CCND1HTR4PDE4DSMPD1 | |
| Hydrochloric Acid SCHEMBL10667216 | 0.82 | HCN4 (0.49) | HCN4BRD4SMPD1MAPTCYP3A4 | |
| SCHEMBL10645664 | 0.81 | HCN4 (0.64) | HCN4CDK4CCND1HTR4PDE4D | |
| SCHEMBL10985132 | 0.79 | HCN4 (0.73) | HCN4BRD4SMPD1MAPTCYP1A2 | |
| SCHEMBL11096818 | 0.79 | HCN4 (0.47) | HCN4BRD4SMPD1MAPTCYP3A4 | |
| SCHEMBL10671624 | 0.79 | HCN4 (0.50) | HCN4BRD4SMPD1MAPTCYP3A4 | |
| SCHEMBL9215673 | 0.79 | HTR1A (0.45) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL11092035 | 0.78 | HCN4 (0.61) | HCN4BRD4SMPD1MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4616011-A | BRADYCARDIAL AND ANTIISCHEMIC AGENTS; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0146787-A2 | Indole derivatives, medicaments containing these compounds, and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1985-07-03 | — | — | EP | disclosed |