Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 11/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.48 |
| ▸ | PDE4A | P27815 | 4/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.46 |
| ▸ | NPY2R | P49146 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21241241 | 0.86 | KCNH2 (0.58) | KCNH2SMN1; SMN2PDE3BPDE3APDE4A | |
| SCHEMBL6559298 | 0.81 | KCNH2 (0.59) | KCNH2SMN1; SMN2PDE3BPDE3APDE4A | |
| SCHEMBL11479531 | 0.81 | KCNH2 (0.56) | KCNH2SMN1; SMN2PDE3BPDE3APDE4A | |
| SCHEMBL2478615 | 0.80 | KCNH2 (0.66) | KCNH2SMN1; SMN2PDE3BPDE3APDE4A | |
| SCHEMBL10353452 | 0.79 | SMN1; SMN2 (0.81) | KCNH2SMN1; SMN2PDE3BPDE3APDE4A | |
| SCHEMBL10375055 | 0.79 | KCNH2 (0.51) | KCNH2SMN1; SMN2PDE3BPDE3APDE4A | |
| SCHEMBL10752098 | 0.79 | KCNH2 (0.51) | KCNH2SMN1; SMN2PDE3BPDE3APDE4A | |
| SCHEMBL10669006 | 0.79 | EPHX1 (0.56) | SMN1; SMN2PDE3BLMNAMAPK1MAPT | |
| Hydrochloric Acid SCHEMBL7295890 | 0.79 | KCNH2 (0.64) | KCNH2SMN1; SMN2PDE3BPDE3APDE4A | |
| SCHEMBL11159064 | 0.79 | KCNH2 (0.57) | KCNH2SMN1; SMN2PDE3BPDE3APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0085985-A1 | Pyridazinone derivatives, pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising said compounds | MITSUBISHI KASEI CORPORATION (JP) | 1983-08-17 | — | — | EP | claimed |
| US-4734415-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1988-03-29 | — | — | US | disclosed |
| EP-0085985-A1 | Pyridazinone derivatives, pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising said compounds | MITSUBISHI KASEI CORPORATION (JP) | 1983-08-17 | — | — | EP | disclosed |