Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1863155 | 0.80 | F2 (0.44) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21826733 | 0.78 | F2 (0.44) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21825683 | 0.78 | F2 (0.44) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21825838 | 0.76 | F2 (0.42) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21826382 | 0.76 | F2 (0.48) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21825839 | 0.76 | F2 (0.42) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21826394 | 0.76 | F2 (0.48) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL3945406 | 0.76 | F2 (0.43) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21825720 | 0.73 | F2 (0.39) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21825722 | 0.73 | F2 (0.39) | F2PLAUKLKB1ELANEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274297-A1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009127546-A1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-10-22 | — | — | WO | disclosed |