Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.43 |
| ▸ | PLAU | P00749 | 3/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.43 |
| ▸ | ELANE | P08246 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1863155 | 0.77 | F2 (0.44) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21826382 | 0.77 | F2 (0.48) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21826394 | 0.77 | F2 (0.48) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21826733 | 0.76 | F2 (0.44) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL1067129 | 0.76 | F2 (0.41) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21825683 | 0.76 | F2 (0.44) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21825838 | 0.74 | F2 (0.42) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21825839 | 0.74 | F2 (0.42) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21826682 | 0.73 | F2 (0.43) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21826680 | 0.73 | F2 (0.43) | F2PLAUKLKB1ELANEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046755-A2 | PYRAZOLES AS GLUCOKINASE ACTIVATORS | F. Hoffmann-Roche AG (CH) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008012227-A2 | PYRAZOLES AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-31 | — | — | WO | disclosed |