Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lansoprazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A known ✓ | P20648 | 4/20 | 0.60 |
| ▸ | ATP4B known ✓ | P51164 | 4/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | WDR5 | P61964 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | ENGASE | Q8NFI3 | 3/20 | 0.60 |
| ▸ | SARM1 | Q6SZW1 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | ATP1A1 | P05023 | 3/20 | 0.60 |
| ▸ | ATP1B1 | P05026 | 3/20 | 0.60 |
| ▸ | ATP1A3 | P13637 | 3/20 | 0.60 |
| ▸ | ATP1B2 | P14415 | 3/20 | 0.60 |
| ▸ | ATP1A2 | P50993 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dexlansoprazole SCHEMBL1067269 | 1.00 | CYP2C9 (0.62) | CYP2C9NPC1RAB9ACYP1A2CYP3A4 | |
| Dexlansoprazole SCHEMBL29353881 | 0.99 | CYP2C9 (0.63) | CYP2C9NPC1RAB9ACYP1A2CYP3A4 | |
| Lansoprazole SCHEMBL1559598 | 0.99 | CYP2C9 (0.63) | CYP2C9NPC1RAB9ACYP1A2CYP3A4 | |
| Lansoprazole SCHEMBL29353345 | 0.99 | CYP2C9 (0.63) | CYP2C9NPC1RAB9ACYP1A2CYP3A4 | |
| Lansoprazole SCHEMBL22366 | 0.99 | CYP2C9 (0.63) | CYP2C9NPC1RAB9ACYP1A2CYP3A4 | |
| Dexlansoprazole SCHEMBL29750802 | 0.99 | CYP2C9 (0.63) | CYP2C9NPC1RAB9ACYP1A2CYP3A4 | |
| Dexlansoprazole SCHEMBL29598842 | 0.99 | CYP2C9 (0.63) | CYP2C9NPC1RAB9ACYP1A2CYP3A4 | |
| Dexlansoprazole SCHEMBL44975 | 0.99 | CYP2C9 (0.63) | CYP2C9NPC1RAB9ACYP1A2CYP3A4 | |
| Lansoprazole SCHEMBL8597994 | 0.99 | CYP2C9 (0.63) | CYP2C9NPC1RAB9ACYP1A2CYP3A4 | |
| Lansoprazole SCHEMBL29358567 | 0.99 | CYP2C9 (0.63) | CYP2C9NPC1RAB9ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 208 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116687961-B | Dry suspension containing lansoprazole and sodium bicarbonate and preparation method thereof | 南京海纳医药科技股份有限公司 | 2025-06-24 | — | — | CN | claimed |
| CN-119666773-A | Analysis method for measuring content of lansoprazole sodium bicarbonate capsule main drug | 上海信谊万象药业股份有限公司 | 2025-03-21 | — | — | CN | claimed |
| CN-119606909-A | Lansoprazole sodium bicarbonate capsule and preparation process thereof | 上海信谊万象药业股份有限公司 | 2025-03-14 | — | — | CN | claimed |
| CN-116687961-A | Dry suspension containing lansoprazole and sodium bicarbonate and preparation method thereof | 南京海纳医药科技股份有限公司 | 2023-09-05 | — | — | CN | claimed |
| CN-115737644-A | Application of lansoprazole in preparing medicine for treating or preventing viral hepatitis | 中以海德人工智能药物研发股份有限公司 | 2023-03-07 | — | — | CN | claimed |
| CN-114191411-B | Proton pump inhibitor capsule and preparation method thereof | 苏州中化药品工业有限公司 | 2023-02-28 | — | — | CN | claimed |
| CN-114224888-B | Application of lansoprazole in preparing medicine for treating or preventing viral hepatitis | 中以海德人工智能药物研发股份有限公司 | 2022-11-01 | — | — | CN | claimed |
| CN-108794450-B | Method for preparing amorphous dexlansoprazole | 浙江恒康药业股份有限公司 | 2022-08-19 | — | — | CN | claimed |
| CN-114224888-A | Application of lansoprazole in preparing medicine for treating or preventing viral hepatitis | 中以海德人工智能药物研发股份有限公司 | 2022-03-25 | — | — | CN | claimed |
| CN-114191411-A | Proton pump inhibitor capsule and preparation method thereof | 苏州中化药品工业有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-101502493-A | Method for preparing lansoprazole freeze-dried injection for injection | YOUCARE PHARMCEUTICAL GROUP CO (CN) | 2009-08-12 | — | — | CN | claimed |
| CN-101475562-A | Method for synthesizing lansoprazole and salt thereof | HAINAN MEIDA PHARMACEUTICAL CO (CN) | 2009-07-08 | — | — | CN | claimed |
| CN-101250182-A | Lansoprazole sodium | JIANGSU AOSAIKANG PHARMACEUTIC (CN) | 2008-08-27 | — | — | CN | claimed |
| CN-100358525-C | Prepn process of Lansoprazole sodium for treating peptic ulcer | JINZHOU JIUTAI PHARMACEUTICAL (CN) | 2008-01-02 | — | — | CN | claimed |
| CN-1883458-A | Enteric coated preparation of lansoprazole sodium and preparation method thereof | JINZHOU JIUTAI PHARMACEUTICAL (CN) | 2006-12-27 | — | — | CN | claimed |
| CN-1810245-A | Prepn process of Lansoprazole sodium for treating peptic ulcer | JINZHOU JIUTAI PHARMACEUTICAL (CN) | 2006-08-02 | — | — | CN | claimed |
| CN-1810244-A | Freeze dried Lansoprazole sodium injection and its prepn process | JINZHOU JIUTAI PHARMACEUTICAL (CN) | 2006-08-02 | — | — | CN | claimed |
| CN-1689568-A | Pharmaceutical composition containing cyclodextrin derivatives and proton pump inhibitor of parietal cell | YIN XIAOFENG (CN) | 2005-11-02 | — | — | CN | claimed |
| CN-1683367-A | Process for preparing lansoprazole sodium salt | BOWEI MEDICINE SCIENCE AND TEC (CN) | 2005-10-19 | — | — | CN | claimed |
| CN-1660092-A | Injection preparation of sodium lansoprazole and preparing method | CHEN QINGCAI (CN) | 2005-08-31 | — | — | CN | claimed |