Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.34 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.32 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.32 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.31 |
| ▸ | LAP3 | P28838 | 2/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Serine SCHEMBL17603641 | 0.89 | SLC7A5 (0.45) | SLC7A5SLC1A1SLC1A3SLC1A2GRIK1 | |
| Serine SCHEMBL5698241 | 0.84 | SLC7A5 (0.33) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 | |
| SCHEMBL3191865 | 0.84 | SLC7A5 (0.33) | SLC7A5 | |
| Serine SCHEMBL9716090 | 0.83 | ALOX15 (0.46) | SLC7A5SLC1A1SLC1A3SLC1A2PDCD1LG2 | |
| Threonine SCHEMBL9716069 | 0.80 | USP2 (0.44) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 | |
| Threonine SCHEMBL1067383 | 0.80 | USP2 (0.44) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 | |
| Threonine SCHEMBL1067389 | 0.80 | USP2 (0.44) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 | |
| Threonine SCHEMBL1697282 | 0.80 | USP2 (0.44) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 | |
| Threonine SCHEMBL9716088 | 0.80 | USP2 (0.44) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 | |
| Serine SCHEMBL1018118 | 0.80 | PTGS1 (0.48) | SLC7A5SLC1A1SLC1A3SLC1A2GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453920-A2 | ANTAGONISTS, USES & METHODS FOR PARTIALLY INHIBITING TNFR1 | Glaxo Group Limited (GB) | 2012-05-23 | — | — | EP | disclosed |
| US-20120107330-A1 | ANTAGONISTS, USES & METHODS FOR PARTIALLY INHIBITING TNFR1 | GLAXO GROUP LIMITED (GB) | 2012-05-03 | — | — | US | disclosed |
| EP-2398827-A2 | IMPROVED ANTI-TNFR1 POLYPEPTIDES, ANTIBODY VARIABLE DOMAINS&ANTAGONISTS | Glaxo Group Limited (GB) | 2011-12-28 | — | — | EP | disclosed |
| US-20110301335-A1 | ANTI-TNFR1 POLYPEPTIDES, ANTIBODY VARIABLE DOMAINS & ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | US | disclosed |
| WO-2011006914-A2 | ANTAGONISTS, USES & METHODS FOR PARTIALLY INHIBITING TNFR1 | GLAXO GROUP LIMITED (GB) | 2011-01-20 | — | — | WO | disclosed |
| WO-2010094720-A2 | IMPROVED ANTI-TNFR1 POLYPEPTIDES, ANTIBODY VARIABLE DOMAINS & ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-08-26 | — | — | WO | disclosed |
| WO-2004039332-A2 | METHODS FOR USING OSTEOCALCIN | ATHERSYS, INC. (US) | 2004-05-13 | — | — | WO | disclosed |
| EP-1244689-A2 | CYTOKINE POLYPEPTIDES AND NUCLEIC ACIDS | Maxygen, Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040257-A2 | MODIFIED IL-12 SUBUNITS AND NUCLEIC ACIDS ENCODING THEM | MAXYGEN, INC. (US) | 2001-06-07 | — | — | WO | disclosed |
| US-5141870-A | Transforming plants with mutant fragment confers herbicide resistance | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-08-25 | — | — | US | disclosed |