Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.52 |
| ▸ | DRD1 | P21728 | 2/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.52 |
| ▸ | BCL2 | P10415 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10674579 | 0.88 | DRD3 (0.60) | SLC6A2SLC6A4DRD3SLC6A3KCNH2 | |
| SCHEMBL9561903 | 0.78 | KCNH2 (0.64) | SLC6A2SLC6A4DRD3SLC6A3KCNH2 | |
| Hydrochloric Acid SCHEMBL9439186 | 0.77 | CYP2D6 (0.65) | SLC6A2SLC6A4DRD3SLC6A3KCNH2 | |
| SCHEMBL12288127 | 0.76 | DRD3 (0.77) | SLC6A2SLC6A4DRD3SLC6A3KCNH2 | |
| SCHEMBL12288130 | 0.76 | DRD3 (0.77) | SLC6A2SLC6A4DRD3SLC6A3KCNH2 | |
| SCHEMBL10672421 | 0.74 | HRH1 (0.71) | SLC6A2SLC6A4DRD3SLC6A3KCNH2 | |
| SCHEMBL14860144 | 0.74 | CACNA2D1 (0.66) | SLC6A2SLC6A4DRD3SLC6A3KCNH2 | |
| SCHEMBL10673606 | 0.74 | DRD3 (0.68) | SLC6A2SLC6A4DRD3SLC6A3KCNH2 | |
| SCHEMBL2730768 | 0.73 | PPARA (0.47) | TDP1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9181170 | 0.73 | DRD3 (0.63) | SLC6A2SLC6A4DRD3SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4757074-A | Antihistamines | BURROUGHS WELLCOME CO. (US) | 1988-07-12 | — | — | US | disclosed |
| EP-0133323-B1 | BENZHYDRYLPIPERAZINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1988-02-03 | — | — | EP | disclosed |
| EP-0133323-A1 | Benzhydrylpiperazines | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-02-20 | — | — | EP | disclosed |