Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 4/20 | 0.68 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.68 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.68 |
| ▸ | DRD1 | P21728 | 3/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.68 |
| ▸ | HTR1A | P08908 | 2/20 | 0.68 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.68 |
| ▸ | BCL2 | P10415 | 1/20 | 0.68 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10677115 | 0.87 | CHRM2 (0.70) | DRD3SLC6A3KCNH2CHRM2ADRA2A | |
| SCHEMBL10674933 | 0.85 | CACNA2D1 (0.55) | DRD3SLC6A3KCNH2CHRM2ADRA2A | |
| Chlorcyclizine SCHEMBL16769331 | 0.82 | KCNH2 (1.00) | DRD3SLC6A3KCNH2CHRM2ADRA2A | |
| Chlorcyclizine SCHEMBL4383 | 0.82 | KCNH2 (1.00) | DRD3SLC6A3KCNH2CHRM2ADRA2A | |
| Chlorcyclizine SCHEMBL13724147 | 0.82 | KCNH2 (1.00) | DRD3SLC6A3KCNH2CHRM2ADRA2A | |
| Chlorcyclizine SCHEMBL12157065 | 0.82 | KCNH2 (1.00) | DRD3SLC6A3KCNH2CHRM2ADRA2A | |
| Chlorcyclizine SCHEMBL321657 | 0.81 | CYP2D6 (1.00) | DRD3SLC6A3KCNH2CHRM2ADRA2A | |
| SCHEMBL9438865 | 0.80 | DRD3 (0.61) | DRD3SLC6A3KCNH2CHRM2ADRA2A | |
| SCHEMBL9438870 | 0.80 | DRD3 (0.61) | DRD3SLC6A3KCNH2CHRM2ADRA2A | |
| SCHEMBL10674579 | 0.79 | DRD3 (0.60) | DRD3SLC6A3KCNH2CHRM2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4757074-A | Antihistamines | BURROUGHS WELLCOME CO. (US) | 1988-07-12 | — | — | US | disclosed |
| EP-0133323-B1 | BENZHYDRYLPIPERAZINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1988-02-03 | — | — | EP | disclosed |
| EP-0133323-A1 | Benzhydrylpiperazines | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-02-20 | — | — | EP | disclosed |