Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.69 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.69 |
| ▸ | EDNRA | P25101 | 1/20 | 0.69 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.69 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | RARB | P10826 | 1/20 | 0.52 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | DPP4 | P27487 | 6/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9437345 | 0.92 | LMNA (0.67) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| Hydrochloric Acid SCHEMBL10669137 | 0.92 | LMNA (0.66) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9437317 | 0.91 | LMNA (0.65) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9437352 | 0.90 | LMNA (0.72) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL10677290 | 0.90 | LMNA (0.71) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9437328 | 0.88 | LMNA (0.67) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9437338 | 0.88 | LMNA (0.67) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9437381 | 0.88 | LMNA (0.66) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL10675814 | 0.86 | LMNA (0.69) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL10680733 | 0.85 | LMNA (0.74) | LMNACYP2C9ATP6V1B2TBXA2REDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4777175-A | (NAPHTHYRIDINE, QUINOLINE) CARBOXYLIC ACID | WARNER-LAMBERT COMPANY (US) | 1988-10-11 | — | — | US | disclosed |
| US-4771054-A | QUINOLINE CARBOXYLIC ACID | WARNER-LAMBERT COMPANY (US) | 1988-09-13 | — | — | US | disclosed |
| US-4665079-A | QUINOLINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1987-05-12 | — | — | US | disclosed |
| US-4638067-A | NAPHTHYRIDINE AND QUINOLINE CARBOXYLIC ACIDS | WARNER-LAMBERT CO. (US) | 1987-01-20 | — | — | US | disclosed |
| EP-0153163-A2 | 7-Substituted-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids; 7-substituted-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acids; their derivatives; and a process for preparing the compounds | WARNER-LAMBERT COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |
| EP-0106489-A2 | Antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1984-04-25 | — | — | EP | disclosed |