Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | PGR | P06401 | 1/20 | 0.71 |
| ▸ | SRC | P12931 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10674517 | 0.88 | MEN1 (0.68) | KMT2AMEN1PGRSRCALDH1A1 | |
| SCHEMBL5166077 | 0.88 | HDAC4 (0.56) | KMT2AMEN1PGRSRCALDH1A1 | |
| SCHEMBL10671773 | 0.86 | MEN1 (0.54) | KMT2AMEN1PGRSRCTP53 | |
| SCHEMBL9200433 | 0.84 | MEN1 (0.55) | KMT2AMEN1PGRSRCALDH1A1 | |
| SCHEMBL10671530 | 0.84 | MEN1 (0.55) | KMT2AMEN1PGRSRCALDH1A1 | |
| SCHEMBL5165239 | 0.83 | MEN1 (0.56) | KMT2AMEN1PGRSRCALDH1A1 | |
| Roquinimex SCHEMBL42132 | 0.83 | KMT2A (1.00) | KMT2AMEN1PGRSRCALDH1A1 | |
| Roquinimex SCHEMBL8169579 | 0.83 | KMT2A (1.00) | KMT2AMEN1PGRSRCALDH1A1 | |
| Roquinimex SCHEMBL29359144 | 0.83 | KMT2A (1.00) | KMT2AMEN1PGRSRCALDH1A1 | |
| SCHEMBL10677325 | 0.82 | MEN1 (0.49) | KMT2AMEN1PGRSRCALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4738971-A | ENHANCED CELL-MEDIATED IMMUNITY; ANTIARTHRITIC AGENTS; NONTOXIC | AKTIEBOLASET LEO (SE) | 1988-04-19 | — | — | US | disclosed |
| US-4547511-A | FOR ENHANCIN CELL-MEDIATED IMMUNITY | AKTIEBOLAGET LEO (SE) | 1985-10-15 | — | — | US | disclosed |
| EP-0059698-B1 | HETEROCYCLIC CARBOXAMIDES, COMPOSITIONS CONTAINING SUCH COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND METHODS OF TREATMENT THEREWITH | AB LEO (SE) | 1985-09-25 | — | — | EP | disclosed |
| EP-0059698-A1 | Heterocyclic carboxamides, compositions containing such compounds, processes for their preparation and methods of treatment therewith | AB LEO (SE) | 1982-09-08 | — | — | EP | disclosed |