Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10678651 | 1.00 | SLC6A3 (0.52) | SLC6A3SLC6A2SLC6A4ESR2ESR1 | |
| SCHEMBL10678658 | 1.00 | SLC6A3 (0.52) | SLC6A3SLC6A2SLC6A4ESR2ESR1 | |
| SCHEMBL10671944 | 0.91 | SLC6A3 (0.57) | SLC6A3SLC6A2SLC6A4NISCH | |
| SCHEMBL10672415 | 0.85 | SLC6A3 (0.73) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL10678871 | 0.85 | SLC6A3 (0.73) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL10676588 | 0.85 | SLC6A3 (0.73) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL10676578 | 0.85 | SLC6A3 (0.73) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL10678885 | 0.85 | SLC6A3 (0.73) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL10671203 | 0.85 | SLC6A3 (0.73) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL10672425 | 0.85 | SLC6A3 (0.73) | SLC6A3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4785007-A | ANTIDEPRESSANTS, P | LABORATOIRES HOECHST S.A. (FR) | 1988-11-15 | — | — | US | disclosed |
| EP-0203308-A2 | 2,3- Or 3,4-diphenyl-gamma-nitrile-ester derivatives for the treatment of kidney insufficiency, and their ring-closure products as psychostimulating and antidepressive medicaments | LABORATOIRES HOECHST S.A. (FR) | 1986-12-03 | — | — | EP | disclosed |