Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.74 |
| ▸ | MEN1 | O00255 | 7/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.74 |
| ▸ | GAA | P10253 | 6/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | RAB9A | P51151 | 4/20 | 0.74 |
| ▸ | NPC1 | O15118 | 3/20 | 0.74 |
| ▸ | MAOA | P21397 | 4/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | EGFR | P00533 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
| ▸ | CASP3 | P42574 | 1/20 | 0.63 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.63 |
| ▸ | RELA | Q04206 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12932196 | 1.00 | MAPT (0.74) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL13186607 | 0.90 | MAPT (0.84) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL12443462 | 0.86 | MEN1 (0.72) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL1435489 | 0.83 | GAA (1.00) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL1435490 | 0.83 | GAA (1.00) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL25613862 | 0.82 | GUSB (0.67) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL17150984 | 0.82 | MAPT (0.76) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL25613768 | 0.82 | GAA (0.68) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL18980780 | 0.82 | MAPT (0.76) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL18980779 | 0.82 | MAPT (0.76) | MAPTMEN1KMT2AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222326-B1 | Inhibitors of MALT1-proteolytic activity and uses thereof | VIB VZW (BE) | 2012-04-18 | — | — | EP | disclosed |
| US-20110021548-A1 | INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF | UNIVERSITEIT GENT (BE) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021548-A1 | INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF | MMEL1, CTRL, ZFR | MAPT 4436/4885MEN1 1339/4885KMT2A 2852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.