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Sugi Predict / Targets / MMEL1

MMEL1

Membrane metallo-endopeptidase-like 1 · Q495T6 · MMEL1 on Sugi Atlas →

8,448 patent compounds predicted against MMEL1, 4,987 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1912665 SCHEMBL1912665 0.65 16/20
SCHEMBL1912527 SCHEMBL1912527 0.76 15/20
SCHEMBL1912518 SCHEMBL1912518 0.68 14/20
SCHEMBL1912523 SCHEMBL1912523 0.68 14/20
SCHEMBL1912528 SCHEMBL1912528 0.62 13/20
SCHEMBL1912661 SCHEMBL1912661 0.62 13/20
SCHEMBL1912636 SCHEMBL1912636 0.78 12/20
SCHEMBL1912639 SCHEMBL1912639 0.78 12/20
SCHEMBL1912590 SCHEMBL1912590 0.67 12/20
SCHEMBL1912658 SCHEMBL1912658 0.53 12/20
SCHEMBL1912606 SCHEMBL1912606 0.74 11/20
SCHEMBL1912650 SCHEMBL1912650 0.70 11/20
SCHEMBL1912653 SCHEMBL1912653 0.70 11/20
SCHEMBL2315240 SCHEMBL2315240 0.63 11/20
SCHEMBL2315245 SCHEMBL2315245 0.63 11/20
SCHEMBL2315341 SCHEMBL2315341 0.63 11/20
SCHEMBL1912631 SCHEMBL1912631 0.62 11/20
SCHEMBL1912634 SCHEMBL1912634 0.62 11/20
SCHEMBL1912600 SCHEMBL1912600 0.61 11/20
SCHEMBL2315526 SCHEMBL2315526 0.59 11/20

Clinical trials — most relevant to MMEL1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Estimation of MMP-8 Levels in GCF and Serum and Its Correlation With Wound Healing and Clinical Outcomes After Coronally Advanced Flap and Subepithelial Connective Tissue Graft for Root Coverage in Recession Defects: A CLINICO-BIOCHEMICAL STUDY PHASE4SUSPENDED
Comparing the Effects of Spironolactone With Chlortalidone on LV Mass in Patients With CKD PHASE4UNKNOWN
EndoTAG-1 in Triple Receptor Negative Breast Cancer Patients PHASE2COMPLETED
Histocompatibility Leukocyte Antigen (HLA)-A*0201 Restricted Peptide Vaccine Therapy in Patients With Esophageal Cancer PHASE1/PHASE2COMPLETED
Human Leukocyte Antigen (HLA) - A*2402 Restricted Peptide Vaccine Therapy in Patients With Advanced Esophageal Cancer PHASE1COMPLETED
Dose Escalation Study of Immunomodulatory Nanoparticles PHASE1ACTIVE_NOT_RECRUITING
The Role of Matrix Metalloproteinases (MMPs) in Orthodontic Tooth Movement PHASE1COMPLETED
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism EARLY_PHASE1UNKNOWN
Evaluation of Different Serum Cartilage Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Subjects nanAVAILABLE
Factors Involved in Asthma and Airway Inflammation nanCOMPLETED
LRP1 and Colon Cancer nanUNKNOWN
The Natural History of Alpha-Mannosidosis nanCOMPLETED
Genome Environment Microbiome and Metabolome in Autism Study nanCOMPLETED
Biomarker for Mucolipidosis Disorder Type I, II, III, IV (BioML) nanWITHDRAWN
Study of Trans-tissular Migration of Macrophages Associated to Human Breast Cancer nanUNKNOWN
Esophageal String Test in Eosinophilic Esophagitis nanACTIVE_NOT_RECRUITING
Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction nanCOMPLETED
Genetic Variants and Regulation of Specialized Pro-resolving Mediator nanRECRUITING
Integrated Proteomic HPLC-ESI-MS Analysis of Salivary Peptides of Preterm Newborns: a Pilot Study nanCOMPLETED
The Genetics of Chiari Type I Malformation nanCOMPLETED
Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis nanCOMPLETED
Proteomics of Primary Hyperoxaluria Type 1 nanCOMPLETED
Biomarkers of Lichen Sclerosus nanUNKNOWN
Clinical Study of Muenke Syndrome (FGFR3-Related Craniosynostosis) nanCOMPLETED
Nuclear Myosin VI - a Therapeutic Target in Breast Cancer nanUNKNOWN
Maternal Genes and Epimutations: Beckwith-Wiedemann Syndrome & Reproductive Risks nanRECRUITING
Respiratory Cathepsins, Proteases Inhibitors and Glycosaminoglycans (GAG) in Mucopolysaccharidosis nanCOMPLETED
Nasal Epithelial Genetic and Single Cell RNA COVID-19 Study nanWITHDRAWN
Plasma Levels of Matrix Metalloproteinases (MMPs) and Degree of DNA Fragmentation in Pseudoexfoliation (PEX) Glaucoma nanCOMPLETED
Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a MMEL1 binder may also engage these)

ProteinNameSimilarity
Q9JLI3 — 1.000 Q9JLI3 →
ECE1 Endothelin-converting enzyme 1 0.999 landscape →
B2RQR8 — 0.997 B2RQR8 →
P0C1T0 — 0.997 P0C1T0 →
F1N476 — 0.995 F1N476 →
P42893 — 0.995 P42893 →
Q4PZA2 — 0.993 Q4PZA2 →
P97739 — 0.992 P97739 →
P0DPE2 — 0.992 P0DPE2 →
Q8IS64 — 0.991 Q8IS64 →
P0DPD9 — 0.991 P0DPD9 →
A0A0B4K692 — 0.991 A0A0B4K692 →
P42891 — 0.991 P42891 →
O95672 — 0.991 O95672 →
ECE2 Endothelin-converting enzyme 2 0.991 landscape →
P07861 — 0.991 P07861 →
Q9JHL3 — 0.990 Q9JHL3 →
Q61391 — 0.990 Q61391 →
Q9JMI0 — 0.990 Q9JMI0 →
Q5RE69 — 0.990 Q5RE69 →
O16796 — 0.989 O16796 →
P08049 — 0.987 P08049 →
P0DPD8 — 0.987 P0DPD8 →
MME Neprilysin 0.987 landscape →
Q18673 — 0.987 Q18673 →
Q9W436 — 0.986 Q9W436 →
W4VS99 — 0.986 W4VS99 →
Q22523 — 0.985 Q22523 →
O44857 — 0.985 O44857 →
Q9W5Y0 — 0.985 Q9W5Y0 →