SCHEMBL10682240

SCHEMBL10682240

COC(=O)C1CCC(F)(F)CC1C(=O)OC

nearest known ligand 0.38

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KCNQ3 O43525 2/20 0.37
KCNQ2 O43526 2/20 0.37
KCNQ4 P56696 1/20 0.37
KCNQ5 Q9NR82 1/20 0.37
EPHX2 P34913 1/20 0.36
CHRM2 P08172 1/20 0.35
CHRM4 P08173 1/20 0.35
CHRM3 P20309 1/20 0.35
CYP1A2 P05177 1/20 0.32
HIF1A Q16665 1/20 0.32
CTSK P43235 1/20 0.31
ALDH1A1 P00352 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16618191 1.00 KCNQ3 (0.37) KCNQ3KCNQ2KCNQ4KCNQ5EPHX2
SCHEMBL16617896 0.91 KCNQ3 (0.37) KCNQ3KCNQ2KCNQ4KCNQ5EPHX2
SCHEMBL16637758 0.91 KCNQ3 (0.37) KCNQ3KCNQ2KCNQ4KCNQ5EPHX2
SCHEMBL16635680 0.90 KCNQ3 (0.33) KCNQ3KCNQ2KCNQ4KCNQ5EPHX2
SCHEMBL16635681 0.90 KCNQ3 (0.33) KCNQ3KCNQ2KCNQ4KCNQ5EPHX2
SCHEMBL17008630 0.90 CHRM2 (0.35) KCNQ3KCNQ2KCNQ4KCNQ5EPHX2
SCHEMBL18279798 0.90 CHRM2 (0.35) KCNQ3KCNQ2KCNQ4KCNQ5EPHX2
SCHEMBL18891973 0.87 CHRM2 (0.38) KCNQ3KCNQ2KCNQ4KCNQ5EPHX2
SCHEMBL24174889 0.86 CHRM2 (0.36) CHRM2CHRM4CHRM3CYP1A2HIF1A
SCHEMBL17756086 0.86 CHRM2 (0.36) CHRM2CHRM4CHRM3CYP1A2HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4792618-A CHEMICAL INTERMEDIATE FOR POLYMERS AND PESTICIDES OCCIDENTAL CHEMICAL CORPORATION (US) 1988-12-20 US disclosed