Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 2/20 | 0.37 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.37 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.37 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.37 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.37 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.37 |
| ▸ | PPM1B | O75688 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16617896 | 1.00 | KCNQ3 (0.37) | KCNQ3KCNQ2KCNQ4KCNQ5SLC6A12 | |
| SCHEMBL16618191 | 0.91 | KCNQ3 (0.37) | KCNQ3KCNQ2KCNQ4KCNQ5EPHX2 | |
| SCHEMBL10682240 | 0.91 | KCNQ3 (0.37) | KCNQ3KCNQ2KCNQ4KCNQ5EPHX2 | |
| SCHEMBL17756085 | 0.85 | GRM4 (0.38) | PPM1BPTPN1PPP1CCTSHRCYP1A2 | |
| SCHEMBL26656015 | 0.85 | GRM4 (0.38) | PPM1BPTPN1PPP1CCTSHRCYP1A2 | |
| SCHEMBL17008630 | 0.85 | CHRM2 (0.35) | KCNQ3KCNQ2KCNQ4KCNQ5POLB | |
| SCHEMBL18279798 | 0.85 | CHRM2 (0.35) | KCNQ3KCNQ2KCNQ4KCNQ5POLB | |
| SCHEMBL10704175 | 0.83 | SLC6A12 (0.45) | KCNQ3KCNQ2KCNQ4KCNQ5SLC6A12 | |
| SCHEMBL18891973 | 0.82 | CHRM2 (0.38) | KCNQ3KCNQ2KCNQ4KCNQ5EPHX2 | |
| SCHEMBL16635680 | 0.82 | KCNQ3 (0.33) | KCNQ3KCNQ2KCNQ4KCNQ5EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051479-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-04-16 | — | — | WO | disclosed |