Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.57 |
| ▸ | XDH | P47989 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10684112 | 0.81 | ADORA2A (0.61) | ADORA2AXDHPDE4APDE4BPDE4C | |
| SCHEMBL12656664 | 0.80 | SMN1; SMN2 (0.68) | SMN1; SMN2ADORA2AXDHMAPTALDH1A1 | |
| SCHEMBL4644252 | 0.78 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL5659777 | 0.76 | SMN1; SMN2 (1.00) | SMN1; SMN2ADORA2AXDHALDH1A1MEN1 | |
| SCHEMBL3854866 | 0.75 | SMN1; SMN2 (0.74) | SMN1; SMN2ADORA2AXDHALDH1A1MEN1 | |
| SCHEMBL15660839 | 0.73 | SMN1; SMN2 (0.71) | SMN1; SMN2ADORA2AXDHMAPTALDH1A1 | |
| SCHEMBL4307418 | 0.72 | GSK3B (0.58) | SMN1; SMN2XDHMAPTALDH1A1KDM4E | |
| SCHEMBL10688603 | 0.72 | PDE4A (0.59) | SMN1; SMN2ADORA2AXDHPDE4APDE4B | |
| SCHEMBL10688346 | 0.71 | KDM4E (0.51) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL10569385 | 0.70 | KDM4E (0.66) | SMN1; SMN2ADORA2APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4725600-A | Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-02-16 | — | — | US | disclosed |
| EP-0168262-A2 | Pyrimidine derivatives, processes for preparation thereof and use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-15 | — | — | EP | disclosed |