Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 7/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10686873 | 0.82 | TDP2 (0.49) | KDM4EALDH1A1MAPTPDE4APDE4B | |
| SCHEMBL10567082 | 0.82 | MEN1 (0.47) | KDM4EALDH1A1MAPTPDE4APDE4B | |
| SCHEMBL10569897 | 0.80 | GSK3B (0.48) | KDM4EALDH1A1MAPTPDE4APDE4B | |
| SCHEMBL10567447 | 0.76 | SYK (0.46) | KDM4EALDH1A1MAPTPDE4APDE4B | |
| SCHEMBL10690149 | 0.76 | KDM4E (0.49) | KDM4EALDH1A1MAPTBRD9PDE4A | |
| SCHEMBL10682640 | 0.75 | MAPT (0.43) | KDM4EALDH1A1MAPTPDE4APDE4B | |
| SCHEMBL10682633 | 0.75 | MAPT (0.43) | KDM4EALDH1A1MAPTPDE4APDE4B | |
| SCHEMBL10685228 | 0.73 | PDE4A (0.51) | KDM4EALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL10688714 | 0.72 | PDE4A (0.47) | KDM4EALDH1A1MAPTPDE4APDE4B | |
| SCHEMBL10683186 | 0.71 | SMN1; SMN2 (0.61) | KDM4EALDH1A1MAPTPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4725600-A | Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-02-16 | — | — | US | disclosed |
| EP-0168262-A2 | Pyrimidine derivatives, processes for preparation thereof and use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-15 | — | — | EP | disclosed |