Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Megestrol Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 6/20 | 0.98 |
| ▸ | AR | P10275 | 7/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.98 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.98 |
| ▸ | LMNA | P02545 | 5/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.98 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.98 |
| ▸ | MEN1 | O00255 | 3/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.98 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.98 |
| ▸ | POLB | P06746 | 1/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.78 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.78 |
| ▸ | USP2 | O75604 | 2/20 | 0.78 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.78 |
| ▸ | THRB | P10828 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Megestrol Acetate SCHEMBL5021332 | 0.99 | AR (1.00) | ARCYP3A4PGRNR3C1LMNA | |
| Megestrol Acetate SCHEMBL8817569 | 0.99 | AR (1.00) | ARCYP3A4PGRNR3C1LMNA | |
| Megestrol Acetate SCHEMBL14071675 | 0.99 | AR (1.00) | ARCYP3A4PGRNR3C1LMNA | |
| Megestrol Acetate SCHEMBL190902 | 0.99 | AR (1.00) | ARCYP3A4PGRNR3C1LMNA | |
| Megestrol Acetate SCHEMBL13660184 | 0.99 | AR (1.00) | ARCYP3A4PGRNR3C1LMNA | |
| Megestrol Acetate SCHEMBL745 | 0.99 | AR (1.00) | ARCYP3A4PGRNR3C1LMNA | |
| Megestrol Acetate SCHEMBL12998544 | 0.99 | AR (1.00) | ARCYP3A4PGRNR3C1LMNA | |
| Megestrol Acetate SCHEMBL13941350 | 0.99 | AR (1.00) | ARCYP3A4PGRNR3C1LMNA | |
| Megestrol Acetate SCHEMBL21281326 | 0.99 | AR (1.00) | ARCYP3A4PGRNR3C1LMNA | |
| Megestrol Acetate SCHEMBL11135443 | 0.98 | AR (0.98) | ARCYP3A4PGRNR3C1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4769463-A | POLYIMIDES | MITSUI TOATSU CHEMICALS, INC. (JP) | 1988-09-06 | — | — | US | disclosed |