Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Megestrol Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 6/20 | 1.00 |
| ▸ | AR | P10275 | 7/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 7/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 3/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.80 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.80 |
| ▸ | USP2 | O75604 | 2/20 | 0.80 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.80 |
| ▸ | THRB | P10828 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Megestrol Acetate SCHEMBL21281326 | 1.00 | AR (1.00) | ARCYP3A4PGRNR3C1LMNA | |
| Megestrol Acetate SCHEMBL5021332 | 1.00 | AR (1.00) | ARCYP3A4PGRNR3C1LMNA | |
| Megestrol Acetate SCHEMBL13660184 | 1.00 | AR (1.00) | ARCYP3A4PGRNR3C1LMNA | |
| Megestrol Acetate SCHEMBL12998544 | 1.00 | AR (1.00) | ARCYP3A4PGRNR3C1LMNA | |
| Megestrol Acetate SCHEMBL190902 | 1.00 | AR (1.00) | ARCYP3A4PGRNR3C1LMNA | |
| Megestrol Acetate SCHEMBL14071675 | 1.00 | AR (1.00) | ARCYP3A4PGRNR3C1LMNA | |
| Megestrol Acetate SCHEMBL745 | 1.00 | AR (1.00) | ARCYP3A4PGRNR3C1LMNA | |
| Megestrol Acetate SCHEMBL13941350 | 1.00 | AR (1.00) | ARCYP3A4PGRNR3C1LMNA | |
| Megestrol Acetate SCHEMBL11135443 | 0.99 | AR (0.98) | ARCYP3A4PGRNR3C1LMNA | |
| Megestrol Acetate SCHEMBL10684908 | 0.99 | AR (0.98) | ARCYP3A4PGRNR3C1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4154748-A | Phosphate catalyzed acylation of steroidal tertiary alcohols | THE UPJOHN COMPANY (US) | 1979-05-15 | — | — | US | claimed |
| US-4054651-A | Method of contraception | RICHARDSON-MERRELL INC. (US) | 1977-10-18 | — | — | US | claimed |
| US-4016270-A | Method for treating dysmenorrhea with a uterine therapeutic system | ALZA CORPORATION (US) | 1977-04-05 | — | — | US | claimed |
| US-4014988-A | Method for treating hypermenorrhea with uterine therapeutic system | ALZA CORPORATION (US) | 1977-03-29 | — | — | US | claimed |
| WO-1997023498-A1 | 18-METHYL 16-METHYLENE 19-NOR PREGNANE DERIVATIVES AS PROGESTINS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THE PREPARATION THEREOF | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 1997-07-03 | — | — | WO | disclosed |
| US-4900734-A | MENOPAUSE SYMPTOMS TREATMENT | MAXSON WAYNE S (US) | 1990-02-13 | — | — | US | disclosed |
| EP-0179496-A1 | 16-Sulfinylmethyl-steroids, their preparation and use | THE UPJOHN COMPANY (US) | 1986-04-30 | — | — | EP | disclosed |
| US-4443377-A | Isomerization-acylation process | THE UPJOHN COMPANY (US) | 1984-04-17 | — | — | US | disclosed |
| EP-0104054-A2 | 16-methylene-steroids and their preparation | THE UPJOHN COMPANY (US) | 1984-03-28 | — | — | EP | disclosed |
| US-4383992-A | Water-soluble steroid compounds | LIPARI JOHN M | 1983-05-17 | — | — | US | disclosed |
| US-4154748-A | Phosphate catalyzed acylation of steroidal tertiary alcohols | THE UPJOHN COMPANY (US) | 1979-05-15 | — | — | US | disclosed |
| US-4034749-A | Intrauterine contraceptive device | SCHERING AKTIENGESELLSCHAFT (DT) | 1977-07-12 | — | — | US | disclosed |