⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9782637 | 0.78 | — | — | |
| SCHEMBL10964946 | 0.77 | — | — | |
| SCHEMBL10700383 | 0.77 | — | — | |
| SCHEMBL11437974 | 0.77 | — | — | |
| SCHEMBL10689099 | 0.77 | — | — | |
| SCHEMBL10964954 | 0.77 | — | — | |
| SCHEMBL11098714 | 0.76 | FAAH (0.30) | — | |
| SCHEMBL11267554 | 0.75 | — | — | |
| SCHEMBL11220168 | 0.75 | — | — | |
| SCHEMBL10999628 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4739048-A | Process for the preparation of thienamycin and intermediates | MERCK & CO., INC. (US) | 1988-04-19 | — | — | US | disclosed |
| US-4610820-A | Process for the preparation of thienamycin and intermediates | MERCK & CO., INC. (US) | 1986-09-09 | — | — | US | disclosed |
| EP-0018594-B1 | PROCESS FOR THE PREPARATION OF 3-(1-HYDROXYETHYL)-AZETIDINONES | MERCK & CO. INC. (US) | 1985-08-21 | — | — | EP | disclosed |
| EP-0007973-B1 | PROCESS FOR THE PREPARATION OF THIENAMYCIN AND INTERMEDIATES | MERCK & CO. INC. (US) | 1984-02-01 | — | — | EP | disclosed |
| US-4400323-A | 3-[1-Hydroxyethyl]-4-carboxymethyl-azetidin-2-one | MERCK & CO., INC. (US) | 1983-08-23 | — | — | US | disclosed |
| US-4378315-A | Process for the preparation of thienamycin and intermediates | MERCK & CO., INC. (US) | 1983-03-29 | — | — | US | disclosed |
| US-4309346-A | INTERMEDIATES FOR AMINO ACID DERIVATIVE ANTIBIOTICS | MERCK & CO., INC. (US) | 1982-01-05 | — | — | US | disclosed |
| EP-0037081-A1 | Process for the preparation of 1-carbapenems and intermediates via trithioorthoacetates | MERCK & CO. INC. (US) | 1981-10-07 | — | — | EP | disclosed |
| US-4290947-A | Process for the preparation of thienamycin and intermediates | MERCK & CO., INC. (US) | 1981-09-22 | — | — | US | disclosed |
| EP-0026816-A1 | Intermediates for the preparation of thienamycin and process for preparing intermediates | MERCK & CO. INC. (US) | 1981-04-15 | — | — | EP | disclosed |
| EP-0007973-A1 | Process for the preparation of thienamycin and intermediates | MERCK & CO. INC. (US) | 1980-02-20 | — | — | EP | disclosed |