Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC8A1 | P32418 | 19/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10681033 | 0.94 | SLC8A1 (0.48) | SLC8A1SLC6A4HRH3 | |
| SCHEMBL10681548 | 0.92 | SLC6A4 (0.47) | SLC8A1SLC6A4HRH3 | |
| SCHEMBL10682088 | 0.86 | SLC6A9 (0.46) | SLC8A1SLC6A4HRH3 | |
| SCHEMBL10680133 | 0.86 | SLC6A4 (0.52) | SLC8A1SLC6A4 | |
| SCHEMBL10678365 | 0.83 | AR (0.59) | SLC6A4HRH3 | |
| SCHEMBL10682463 | 0.81 | MAOB (0.59) | — | |
| SCHEMBL10678375 | 0.81 | MAOB (0.59) | — | |
| SCHEMBL4953049 | 0.81 | SLC8A1 (0.61) | SLC8A1 | |
| SCHEMBL23999758 | 0.80 | SLC6A4 (0.45) | SLC6A4HRH3 | |
| SCHEMBL10678381 | 0.80 | SLC6A4 (0.45) | SLC6A4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4780478-A | Aminopropoxy-chromones useful as antidepressants | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKTER HAFTUNG (DE) | 1988-10-25 | — | — | US | disclosed |
| US-4508732-A | Basic ethers useful as antidepressant agents | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-04-02 | — | — | US | disclosed |
| EP-0031885-B1 | BASIC ETHERS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION | MERCK PATENT GmbH (DE) | 1984-06-27 | — | — | EP | disclosed |
| US-4376123-A | Hexahydroazepinyloxy-chromones useful as antidepressants | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1983-03-08 | — | — | US | disclosed |
| EP-0031885-A1 | Basic ethers, pharmaceutical compositions containing them and process for their preparation | MERCK PATENT GmbH (DE) | 1981-07-15 | — | — | EP | disclosed |