Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levorphanol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 4/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.96 |
| ▸ | MAPT | P10636 | 1/20 | 0.96 |
| ▸ | BLM | P54132 | 1/20 | 0.96 |
| ▸ | LMNA | P02545 | 1/20 | 0.96 |
| ▸ | HTT | P42858 | 1/20 | 0.96 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.96 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.96 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.80 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.78 |
| ▸ | GRIN2A | Q12879 | 7/20 | 0.78 |
| ▸ | GRIN2D | O15399 | 6/20 | 0.78 |
| ▸ | GRIN3B | O60391 | 6/20 | 0.78 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.78 |
| ▸ | GRIN2C | Q14957 | 6/20 | 0.78 |
| ▸ | GRIN3A | Q8TCU5 | 6/20 | 0.78 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.78 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.78 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.78 |
| ▸ | SCN1A | P35498 | 2/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levorphanol SCHEMBL194174 | 0.99 | CYP2D6 (0.98) | CYP2D6MAPTBLMLMNAHTT | |
| Levorphanol SCHEMBL120615 | 0.99 | CYP2D6 (0.98) | CYP2D6MAPTBLMLMNAHTT | |
| Levorphanol SCHEMBL17598076 | 0.99 | CYP2D6 (0.98) | CYP2D6MAPTBLMLMNAHTT | |
| Levorphanol SCHEMBL29363177 | 0.99 | CYP2D6 (0.98) | CYP2D6MAPTBLMLMNAHTT | |
| Levorphanol SCHEMBL443051 | 0.99 | CYP2D6 (0.98) | CYP2D6MAPTBLMLMNAHTT | |
| Dextrorphan SCHEMBL728534 | 0.98 | CYP2D6 (1.00) | CYP2D6MAPTBLMLMNAHTT | |
| Dextrorphan SCHEMBL30546365 | 0.98 | CYP2D6 (1.00) | CYP2D6MAPTBLMLMNAHTT | |
| Levorphanol SCHEMBL120616 | 0.98 | CYP2D6 (1.00) | CYP2D6MAPTBLMLMNAHTT | |
| Levorphanol SCHEMBL31276780 | 0.91 | CYP2D6 (0.87) | CYP2D6MAPTBLMLMNAHTT | |
| Levorphanol SCHEMBL442898 | 0.91 | OPRD1 (0.87) | CYP2D6MAPTBLMLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4777174-A | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same | ANALGESIC ASSOCIATES (US) | 1988-10-11 | — | — | US | disclosed |