Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 3/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | CA4 | P22748 | 3/20 | 0.53 |
| ▸ | CA7 | P43166 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8423100 | 0.85 | CA1 (0.44) | LMNACA1CA2CA4CA7 | |
| SCHEMBL10685501 | 0.83 | LMNA (0.58) | LMNAKMT2AMEN1L3MBTL1POLB | |
| SCHEMBL10692607 | 0.76 | KMT2A (0.56) | LMNACA1CA2CA4CA7 | |
| SCHEMBL14276831 | 0.72 | HSD17B2 (0.48) | LMNAKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL8207714 | 0.72 | KMT2A (0.52) | LMNAKMT2AALDH1A1MAPTALOX15 | |
| SCHEMBL10691721 | 0.72 | LMNA (0.53) | LMNAKMT2AMEN1L3MBTL1POLB | |
| SCHEMBL3980392 | 0.72 | KMT2A (0.52) | LMNAKMT2AALDH1A1MAPTALOX15 | |
| SCHEMBL8528135 | 0.72 | KMT2A (0.52) | LMNAKMT2AALDH1A1MAPTALOX15 | |
| SCHEMBL22492017 | 0.71 | KMT2A (0.67) | LMNAKMT2AMEN1POLBHTT | |
| SCHEMBL22831278 | 0.71 | KMT2A (0.67) | LMNAKMT2AMEN1POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4731457-A | 1-substituted, 2,3-diphenyl-3-hydroxymethyl pyrrolidines, where the 2- and/or 3-phenyl can be substituted | THE PURDUE FREDERICK COMPANY (US) | 1988-03-15 | — | — | US | disclosed |
| US-4639529-A | Analgesic and anti-inflammatory compounds | THE PURDUE FREDERICK COMPANY (US) | 1987-01-27 | — | — | US | disclosed |