Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 13/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 11/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.42 |
| ▸ | PDE4A | P27815 | 4/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.42 |
| ▸ | PDE5A | O76074 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10547163 | 0.78 | PBRM1 (0.43) | PBRM1PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL10547986 | 0.75 | PDE3B (0.50) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL10521022 | 0.70 | PDE3B (0.58) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL10521017 | 0.70 | PDE3B (0.48) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL10551547 | 0.68 | PDE3A (0.61) | PBRM1PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL10353457 | 0.65 | PDE3B (0.71) | PBRM1PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL16157002 | 0.64 | PDE3B (0.61) | PBRM1PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL7296342 | 0.64 | PDE3B (0.61) | PBRM1PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL8363953 | 0.64 | ADORA2A (0.44) | — | |
| SCHEMBL3124266 | 0.63 | PDE3A (0.60) | PBRM1PDE3APDE3BPDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255704-A2 | Pyridazinone derivatives, process for their preparation and their use as medicines | Roche Diagnostics GmbH (DE) | 1988-02-10 | — | — | EP | disclosed |