Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10689261 | 0.86 | FGFR1 (0.33) | — | |
| SCHEMBL10687474 | 0.82 | NEK2 (0.40) | HSP90AA1HSP90AB1 | |
| SCHEMBL10689477 | 0.82 | DHFR (0.39) | — | |
| SCHEMBL10691189 | 0.81 | DHFR (0.40) | HSP90AA1HSP90AB1 | |
| SCHEMBL10687469 | 0.80 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1 | |
| SCHEMBL10687297 | 0.79 | DHFR (0.47) | — | |
| SCHEMBL10803047 | 0.76 | GAA (0.42) | — | |
| SCHEMBL8207060 | 0.68 | DHFR (0.36) | — | |
| SCHEMBL10687594 | 0.68 | SMN1; SMN2 (0.41) | — | |
| SCHEMBL10687580 | 0.67 | MEN1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4774249-A | Pyrimidine derivatives for treating malaria | HOFFMANN-LA ROCHE INC. (US) | 1988-09-27 | — | — | US | disclosed |
| EP-0122580-B1 | PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1987-10-28 | — | — | EP | disclosed |
| US-4590270-A | 2,4-diamino-[4-piperidinyl]pyrimidines useful as antibacterial agents, antimalarial agents, antitumors agents | HOFFMANN-LA ROCHE INC. (US) | 1986-05-20 | — | — | US | disclosed |
| EP-0122580-A1 | Pyrimidine derivatives, their preparation and pharmaceutical compositions | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-10-24 | — | — | EP | disclosed |